Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
20 authors.
Masayasu ToyomotoDepartment of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.ORCID 0000-0002-3110-1387
Takashi KuriharaDepartment of Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.ORCID 0000-0003-4001-6771
Takayuki NakagawaDepartment of Clinical Pharmacology and Pharmacotherapy, School of Pharmaceutical Sciences, Wakayama Medical University, Wakayama 640-8156, Japan.
Asuka InoueMolecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi 980-8578, Japan.ORCID 0000-0003-0805-4049
Ryo KimuraDepartment of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Isao KiiDepartment of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Teruo SawadaDepartment of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Takashi OgiharaDepartment of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto 606-8507, Japan.ORCID 0000-0002-2068-2411
Kazuki NagayasuDepartment of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Takayuki KishiMolecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi 980-8578, Japan.
Hiroshi OnogiDepartment of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.ORCID 0000-0002-4441-4497
Dohyun ImDepartment of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Hidetsugu AsadaDepartment of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
So IwataDepartment of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.ORCID 0000-0003-1735-2937
Jumpei TaguchiLaboratory for Biomaterials and Bioengineering, Institute of Integrated Research, Institute of Science Tokyo, Tokyo 101-0062, Japan.ORCID 0000-0003-2337-9132
Yuto SumidaLaboratory for Biomaterials and Bioengineering, Institute of Integrated Research, Institute of Science Tokyo, Tokyo 101-0062, Japan.
Suguru YoshidaLaboratory for Biomaterials and Bioengineering, Institute of Integrated Research, Institute of Science Tokyo, Tokyo 101-0062, Japan.
Junken AokiDepartment of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.ORCID 0000-0001-9435-1896
Takamitsu HosoyaLaboratory for Biomaterials and Bioengineering, Institute of Integrated Research, Institute of Science Tokyo, Tokyo 101-0062, Japan.ORCID 0000-0002-7270-351X
Masatoshi HagiwaraDepartment of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.ORCID 0000-0003-1193-7571
Funding
Japan Agency for Medical Research and Development (AMED) JP161m0103006j0005Japan Agency for Medical Research and Development (AMED) JP16bk0104034h0003Japan Agency for Medical Research and Development (AMED) JP16gm0510008Japan Agency for Medical Research and Development (AMED) JP16lk0103007h0005Japan Agency for Medical Research and Development (AMED) JP18am0101092Japan Agency for Medical Research and Development (AMED) JP18bm0804007h0002Japan Agency for Medical Research and Development (AMED) JP18kk0305003h0003Japan Agency for Medical Research and Development (AMED) JP19ek0109310h0002Japan Agency for Medical Research and Development (AMED) JP19gm0010004Japan Agency for Medical Research and Development (AMED) JP19gm5910013Japan Agency for Medical Research and Development (AMED) JP20am0101095Japan Agency for Medical Research and Development (AMED) JP20pc0101063Japan Agency for Medical Research and Development (AMED) JP21am0101092Japan Agency for Medical Research and Development (AMED) JP21am0101098Japan Agency for Medical Research and Development (AMED) JP22ama121038Japan Agency for Medical Research and Development (AMED) JP22zf0127007MEXT | Japan Science and Technology Agency (JST) JPMJFR215TMEXT | Japan Science and Technology Agency (JST) JPMJMS2023MEXT | Japan Science and Technology Agency (JST) JPMJST2181Ministry of Education, Culture, Sports, Science and Technology (MEXT) JP15H05721Ministry of Education, Culture, Sports, Science and Technology (MEXT) JP21H04791Ministry of Education, Culture, Sports, Science and Technology (MEXT) JP21H05037Ministry of Education, Culture, Sports, Science and Technology (MEXT) JP21H05042Ministry of Education, Culture, Sports, Science and Technology (MEXT) JP21H05113Ministry of Education, Culture, Sports, Science and Technology (MEXT) JP22K08282Ministry of Education, Culture, Sports, Science and Technology (MEXT) JP24K21281
6 · The paper itself
Abstract
Noradrenaline is a major monoaminergic neurotransmitter involved in pain modulation through an α2A-adrenergic receptor. Hence, α2-adrenergic agonists such as clonidine and dexmedetomidine exhibit analgesic and opioid-sparing effects. However, their use is restricted to hospital settings due to potential risks of acute hypertension/hypotension and bradycardia. Here, we report that (
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Discovery and development of an oral analgesic targeting the α2B adrenoceptor. · full record | OpenQuestion