ArticleProceedings of the National Academy of Sciences of the United States of America2025
Evaluating plant growth-defense trade-offs by modeling the interaction between primary and secondary metabolism.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Article
- Temperature-Associated Anatomical, Photosynthetic, and Putative GC-MS Metabolomic Profiles in the Arid SpeciesMetabolites · 2026Article
- Structural Variation and Its Roles in Plant Genomes.Plants (Basel, Switzerland) · 2026Review
- A genome-scale metabolic model of a pathosystem sheds light on bacterial wilt.Plant physiology · 2026Article
- Multiomics reveals postherbivory tea leaves restructure endophytic microbiota to resist disease and boost saccharide metabolism to promote growth.Horticulture research · 2026Article
- Article
- Optimizing Tomato Seed Performance Through Cold Atmospheric Plasma: Effects on Germination Rates and Early Biomass Development.Plants (Basel, Switzerland) · 2026Article
- Ethylene as the Molecular Coordinator of the Plant Growth-Defense Trade-Off Under Biotic and Abiotic Stresses.International journal of molecular sciences · 2026Review
- Identification of Potential Candidate Dwarf Genes in Maize by BSA-Seq and Transcriptomic Analyses.Plants (Basel, Switzerland) · 2026Article
- Seasonal Variation and Genetic Evaluation of Needle Catechin Content in Half-Sib Families ofPlants (Basel, Switzerland) · 2026Article
- Unlocking salt tolerance from Fertile Crescent wild barley: evolutionary and physiological mechanisms in introgressed lines.Scientific reports · 2026Article
- Specialized Metabolic Reprogramming in Plant Immunity: Biosynthetic Networks, Spatiotemporal Regulation, and Quantitative Defense.Plants (Basel, Switzerland) · 2026Review
- Unraveling the metabolic regulation of Eleutherococcus senticosus leaves by Penicillium oxalicum: insights from targeted and non-targeted metabolomics.BMC plant biology · 2026Article
- Plant Immunometabolism: Metabolic Reprogramming Linking Developmental Signaling and Defense Metabolites.International journal of molecular sciences · 2026Review
- A Comparative Study of Phenolics in Green Husks of Selected Hungarian Walnut Cultivars.Plants (Basel, Switzerland) · 2026Article
- Temperature-Directed Reprogramming of Volatile and Semi-Volatile Metabolism inInternational journal of molecular sciences · 2026Article
- Metabolic and Biochemical Responses of Heirloom and Hybrid Tomato (Solanum lycopersicum) Under Flooding, Specialist, and Generalist Insect Herbivory, and their Stress Combination.Journal of chemical ecology · 2026Article
- Integrated Omic Analyses Reveal Module Networks Regulating Growth and Bioactive Component Synthesis ofPlants (Basel, Switzerland) · 2026Article
- Metabolic reprogramming of tomato roots during rhizobacteria-mediated defense againstFrontiers in plant science · 2026Article
- CtChi19: a valuable gene for improving resistance to Botrytis cinerea and Alternaria alternata in Carthamus tinctorius.Frontiers in plant science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Understanding the molecular mechanisms behind plant response to stress can enhance breeding strategies and help us design crop varieties with improved stress tolerance, yield, and quality. To investigate resource redistribution from growth- to defense-related processes in an essential tuber crop, potato, here we generate a large-scale compartmentalized genome-scale metabolic model (GEM), potato-GEM. Apart from a large-scale reconstruction of primary metabolism, the model includes the full known potato secondary metabolism, spanning over 566 reactions that facilitate the biosynthesis of 182 distinct potato secondary metabolites. Constraint-based modeling identifies that the activation of the largest amount of secondary (defense) pathways occurs at a decrease of the relative growth rate of potato leaf, due to the costs incurred by defense. We then obtain transcriptomics data from experiments exposing potato leaves to two biotic stress scenarios, a herbivore and a viral pathogen, and apply them as constraints to produce condition-specific models. We show that these models recapitulate experimentally observed decreases in relative growth rates under treatment as well as changes in metabolite levels between treatments, enabling us to pinpoint the metabolic rewiring underlying growth-defense trade-offs. Potato-GEM thus presents a useful resource to study and broaden our understanding of potato and general plant defense responses under stress conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.