Evidence map›Paper›PMID 40773103›Full record

SynthesisAIDS and behavior2026

Male Circumcision and HIV Risk Compensation Among Men Who Have Sex with Men: A Systematic Review and Meta-Analysis.

Xinsheng Wu, Zhongwen Wang, Yongjian Shi, Thomas Fitzpatrick, Weijie Zhang, Zixin Wang, Phoenix K H Mo, Luyao Xie, Yu Liu, Domingo Fernández Vecilla and 6 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in AIDS and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Xinsheng Wu *School of Public Health, Fudan University, Shanghai, China.
Zhongwen Wang *School of Public Health, Fudan University, Shanghai, China.
Yongjian ShiSchool of Public Health, Fudan University, Shanghai, China.
Thomas FitzpatrickSchool of Medicine, University of Washington, Seattle, WA, USA.
Weijie ZhangSchool of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China.
Zixin WangJC School of Public Health and Primary Care, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong SAR, China.
Phoenix K H MoCentre for Health Behaviours Research, School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong SAR, China.
Luyao XieCentre for Health Behaviours Research, School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong SAR, China.
Yu LiuDivision of Epidemiology, Department of Public Health Sciences (SRB 3305), University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Domingo Fernández VecillaMarques de Valdecilla University Hospital, School of Medicine, University of Cantabria, Av. Valdecilla, 25, 39008, Santander, Cantabria, Spain.
Qianqian LuoSchool of Nursing, Binzhou Medical University, Yantai, China.
Aidi ZhangThe Third, Xiangya Hospital of Central South University, Changsha, China.
Ana Claudia Ossa-GiraldoInfettare Research Group, School of Medicine, Universidad Cooperativa de Colombia, Medellín, Colombia.
Kate M MitchellDepartment of Nursing and Community Health, Glasgow Caledonian University London, London, UK.
Sten H VermundCollege of Public Health, University of South Florida, Tampa, FL, USA.
Huachun ZouSchool of Public Health, Fudan University, Shanghai, China. zouhuachun@fudan.edu.cn.ORCID http://orcid.org/0000-0002-8161-7576

Funding

National Key Technologies R&D Program 2023YFC2306700
6 · The paper itself

Abstract

Male circumcision (MC) has been shown to reduce the risk of HIV infection among men who have sex with men (MSM) in a recent randomised controlled trial. A question that remains unanswered is whether MC in MSM implies HIV compensation, i.e. condomless sex and/or multiple sex partners. We searched PubMed, Embase, and the Cochrane Library for relevant studies published before November 5, 2024 and reviewed references of included studies. We included interventional and observational studies reporting original quantitative data on the association between MC and condom use or the number of sex partners among MSM. Odds ratios (ORs) and 95% confidence intervals (CIs) were extracted directly from the studies or calculated from available data when necessary. A Mantel-Haenszel random effects model was used to calculate pooled ORs and CIs. The final analysis included 41,694 MSM from 15 eligible studies. No statistically significant association was found between MC and condomless sex (OR 1.02, 95% CI 0.91-1.14; k = 13; I

Indexed as

Circumcision, MaleHIV InfectionsHomosexuality, MaleUnsafe SexCondomsHumansMaleSexual BehaviorSexual PartnersCondomless sexHIV/AIDSMale circumcision (MC)Men who have sex with men (MSM)Multiple sex partnersRisk compensation

Identifiers

PMID40773103

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.