Evidence map›Paper›PMID 40773101›Full record

ArticleActa neurochirurgica2025

White matter microdissection of the lateral aspect of the brain: 2-dimensional video demonstration.

Luca Zanuttini, Victor E Staartjes, Shao-Ching Chen, Chun-Fu Lin, Sanford P C Hsu, Carolina Martins, Hung Tzu Wen, Carlo Serra, Uğur Türe

Abstract readVideo-Audio Media
In one paragraph

Article in Acta neurochirurgica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Luca ZanuttiniMachine Intelligence in Clinical Neuroscience & Microsurgical Neuroanatomy (MICN) Laboratory, Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland.
Victor E StaartjesMachine Intelligence in Clinical Neuroscience & Microsurgical Neuroanatomy (MICN) Laboratory, Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland.
Shao-Ching ChenDepartment of Surgery, Division of Neurosurgery, Cheng Hsin General Hospital, Taipei, Taiwan.
Chun-Fu LinDivision of General Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Sanford P C HsuDivision of General Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Carolina MartinsNeurology and Neurosurgery Unit, Hospital das Clínicas, Federal University of Pernambuco, Recife, Brazil.
Hung Tzu WenDivision of Neurosurgery, Hospital das Clínicas, University of São Paulo, College of Medicine, São Paulo, Brazil.
Carlo Serra *Machine Intelligence in Clinical Neuroscience & Microsurgical Neuroanatomy (MICN) Laboratory, Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland. carlo.Serra@usz.ch.
Uğur Türe *Department of Neurosurgery, Yeditepe University School of Medicine, Istanbul, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe white matter dissection technique owes its modern recognition to Josef Klingler, whose fixation protocol enabled detailed fiber bundle visualization and led to an outstanding and still relevant atlas of white matter anatomy. After a period of decline in the late twentieth century, the technique was reintroduced into neurosurgical training with the aid of the surgical microscope, emphasizing the importance of fiber dissection and its practical applications in clinical neuroanatomy. This article provides a structured, step-by-step demonstration of white matter microdissection, progressing from superficial anatomy to deeper fiber layers. Its main contribution is the supplementary video, which offers a detailed, structured demonstration of the dissection steps and white matter layers, replicating the format and clarity of hands-on dissection courses. Careful editing and post-processing were applied to optimize educational impact.

methodsThe dissection was recorded during the 7th Sulci, Gyri, Ventricles and Fiber Dissection Hands-on Course (Taipei, November 2024). Identifiable participants gave informed consent for publication.

resultsThe video illustrates a systematic lateral-to-medial dissection, beginning with sulcal and gyral identification. Grey matter is removed to expose U-fibers, followed by progressive visualization of the superior longitudinal fasciculus, insular cortex, extreme and external capsules, claustrum, basal ganglia, and anterior commissure. Each step is accompanied by commentary and technical tips to guide the dissection and preserve anatomical integrity.

conclusionBy mastering the topography of white matter, neurosurgeons can enhance their understanding of pathological anatomy, allowing for precise mental rehearsal and strategic planning before surgery. This approach underscores the enduring importance of anatomical studies in improving surgical outcomes and advancing neurosurgical practice.

Indexed as

BrainMicrodissectionNeuroanatomyWhite MatterHumansNeurosurgical ProceduresFiber dissectionKlinglerMicroneurosurgeryWhite matter

Identifiers

PMID40773101
PMCPMC12331780

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.