ArticleJournal of neurology2025
Predictive clinical factors for the progression from idiopathic late-onset cerebellar ataxia to multiple system atrophy cerebellar type.
Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- A Case Report of Reversible Mitochondrial Bioenergetic Dysfunction in PBMCs in Anti-GAD65-Associated Cerebellar Ataxia.Cerebellum (London, England) · 2026Article
- The role of neurofilament light chain and other fluid biomarkers in cerebellar ataxias.Brain communications · 2026Review
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Authors and funding
7 authors.
Funding
Abstract
objectivesPatients initially diagnosed with idiopathic late-onset cerebellar ataxia (ILOCA) may develop multiple system atrophy cerebellar type (MSA-C). However, data on conversion time, associated clinical factors, and the role of the neurofilament light chain (NFL) in this process remain limited. This study aims to investigate the conversion from ILOCA to MSA-C and examine the associated factors and the predictive value of NFL.
methodsThis retrospective study included patients with ILOCA at the initial visit, recording the conversion to MSA-C and its duration. The median time to conversion was estimated using the Kaplan-Meier analysis. The roles of baseline orthostatic dizziness, rapid eye movement sleep behavior disorder (RBD), hot cross-bun sign, and urinary symptoms in conversion were analyzed. In a subset of patients, NFL levels in plasma collected before conversion were measured to examine their ability to predict conversion.
resultsSeventy-two patients with ILOCA at the initial visit were included, of whom 32 experienced conversion to MSA-C. The median time-to-conversion was 5.0 years. RBD or orthostatic dizziness at baseline was associated with conversion, whereas hot cross-bun sign and urinary symptoms demonstrated no significant effect. Receiver operating characteristic analysis revealed moderate discriminative ability (area under the curve: 0.69) when NFL, orthostatic dizziness, and age at blood collection were included.
conclusionThis study identified that orthostatic dizziness and RBD, assessable in outpatient settings, correlated with ILOCA-to-MSA-C progression. Additionally, the NFL may play an auxiliary role in estimating the conversion time. Therefore, further studies incorporating diverse clinical and serological markers are required.
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