Evidence map›Paper›PMID 40773047›Full record

ArticleMikrochimica acta2025

Simplified ratiometric electrochemiluminescence aptasensor for carcinoembryonic antigen detection based on unmodified aptamer using single luminophore and coreactant.

Zhen Gao, Lei Shang, Wei Zhang, Li-Ping Jia, Rong-Na Ma, Xiao-Jian Li, Huai-Sheng Wang

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhen GaoDepartment of Chemistry, Liaocheng University, Liaocheng, Shandong, 252059, People's Republic of China.
Lei ShangDepartment of Chemistry, Liaocheng University, Liaocheng, Shandong, 252059, People's Republic of China. shanglei@lcu.edu.cn.
Wei ZhangDepartment of Chemistry, Liaocheng University, Liaocheng, Shandong, 252059, People's Republic of China.
Li-Ping JiaDepartment of Chemistry, Liaocheng University, Liaocheng, Shandong, 252059, People's Republic of China.
Rong-Na MaDepartment of Chemistry, Liaocheng University, Liaocheng, Shandong, 252059, People's Republic of China.
Xiao-Jian LiDepartment of Chemistry, Liaocheng University, Liaocheng, Shandong, 252059, People's Republic of China.
Huai-Sheng WangDepartment of Chemistry, Liaocheng University, Liaocheng, Shandong, 252059, People's Republic of China.

Funding

Natural Science Foundation of Shandong Province ZR2018BB059
6 · The paper itself

Abstract

Ratiometric electrochemiluminescence (ECL) aptasensors have garnered significant interest in bioanalysis by simultaneously measuring two distinct emission signals and utilizing their intensity ratio for quantitative output. However, conventional designs face critical limitations. Mandatory aptamer functionalization elevates fabrication complexity and costs. Additionally, dual-luminophore/coreactant systems often suffer from inherent signal mutual interference. To address these issues, we developed a novel ratiometric ECL aptasensing platform employing a single luminophore (luminol) and coreactant (H

Indexed as

Aptamers, NucleotideBiosensing TechniquesCarcinoembryonic AntigenElectrochemical TechniquesLuminescent MeasurementsG-QuadruplexesHeminHumansHydrogen PeroxideLimit of DetectionLuminescent AgentsLuminolAptamers, NucleotideCarcinoembryonic AntigenHeminHydrogen PeroxideLuminescent AgentsLuminolCarcinoembryonic antigenDual-potential detectionG-quadruplexHeminRatiometric aptasensor

Identifiers

PMID40773047

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.