Evidence map›Paper›PMID 40773038›Full record

ArticleProbiotics and antimicrobial proteins2026

Enterococcus Durans J396 Isolated from the Intestine of a Pig Enhances the Antioxidant Activity in Caenorhabditis Elegans.

Juntong Yu, Ruyi Gao, Zhuoming Sun, Wenyu Li, Dongyu Zhao, Tianxu Pan, Jialin Guo, Tongxuan Zhang, Shuyuan Yu, Haibin Huang and 11 more

Abstract read
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In one paragraph

Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Juntong YuCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, China.
Ruyi GaoCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, China.
Zhuoming SunCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, China.
Wenyu LiCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, China.
Dongyu ZhaoCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, China.
Tianxu PanCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, China.
Jialin GuoCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, China.
Tongxuan ZhangCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, China.
Shuyuan YuCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, China.
Haibin HuangCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, China.
Nan WangCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, China.
Chunwei ShiCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, China.
Xuanrui LiuCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, China.
You YangCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, China.
Yukai ZhaoCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, China.
Ya WangCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, China.
Xueting WangCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, China.
Mingxiao LiuCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, China.
Chunfeng WangCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, China.
Jiayao GuanCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, China. g6945636@126.com.
Guilian YangCollege of Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, China. yangguilian@jlau.edu.cn.

Funding

Innovative Research Group Project of the National Natural Science Foundation of China 32072888the China Agriculture Research System of MOF and MARA CARS-35the National Key R&D Program of China 2023YFD1800302the National Natural Science Foundation of China U21A20261the Science and Technology Development Program of Jilin Province 20220202057NC
6 · The paper itself

Abstract

Enterococcus durans is a potential probiotic with beneficial for the health of people and animals. However, the understanding of the antioxidant activity of E. durans is limited. In this study, the antioxidant activity of E. durans isolate J396 was investigated. The strain was well tolerant to heat stress and showed extensively resistant to acid and bile salts. In vitro, the DPPH radical scavenging ability of J396 was 89.95%. Feeding of Caenorhabditis elegans with J396 did not affect nematodes growth and reproduction, and significantly prolonged the lifespan of the nematodes. In addition, the superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-px), and total antioxidant capacity (T-AOC) activities increased by 57.05%, 36.25%, 82.88%, and 49.96%, respectively. The malondialdehyde (MDA), lipofuscin, and reactive oxygen species (ROS) levels were reduced by 28.40%, 28.72%, and 65.57%, respectively. E. durans J396 effectively protected C. elegans from hydrogen peroxide-induced oxidative stress damage. The activity of SOD, CAT, GSH-px, and T-AOC increased by 142.03%, 74.86%, 62.01%, and 94.16%, respectively. Feeding E. durans J396 to C. elegans decreased MDA, lipofuscin, and ROS by 33.59%, 19.70%, and 56.42%, respectively. RT-qPCR analysis showed that the feeding of C. elegans with J396 upregulated the expressions levels of nsy-1, pmk-1, skn-1, and sod-3 in C. elegans. Our study confirmed the antioxidant properties of E. durans J396, indicating its potential application in the pharmaceutical industry and the antioxidant therapy for animals.

Indexed as

AntioxidantsCaenorhabditis elegansEnterococcusIntestinesProbioticsAnimalsCaenorhabditis elegans ProteinsCatalaseGlutathione PeroxidaseOxidative StressReactive Oxygen SpeciesSuperoxide DismutaseAntioxidantsCaenorhabditis elegans ProteinsCatalaseGlutathione PeroxidaseReactive Oxygen SpeciesSuperoxide DismutaseAntioxidant activityCaenorhabditis elegansEnterococcus duransOxidative stressProbiotics

Identifiers

PMID40773038

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.