SynthesisThe international journal of cardiovascular imaging2025
Diagnostic accuracy of discovery NM 530c CZT SPECT for myocardial perfusion imaging in coronary artery disease: a systematic review and meta-analysis.
Synthesis in The international journal of cardiovascular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Platform-specific impact of CT attenuation correction on CZT myocardial perfusion SPECT: per-vessel detection of obstructive coronary artery disease.The international journal of cardiovascular imaging · 2026Article
- Comparison of Non-Invasive and Invasive Diagnostic Methods for Coronary Artery Disease: Single-Centre Data.Medicina (Kaunas, Lithuania) · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Funding
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Abstract
Coronary artery disease (CAD) is the leading cause of cardiovascular mortality (CVD), accounting for 1 in 5 CVD-related deaths. The advent of non-invasive imaging modalities has driven the use of myocardial perfusion imaging (MPI) to enhance diagnostic accuracy and improve clinical outcomes in CAD. Building on the role of myocardial perfusion imaging (MPI), this meta-analysis assesses the diagnostic accuracy of the Discovery NM 530c CZT SPECT for CAD compared with invasive coronary angiography (ICA ± FFR) and noninvasive modalities, including PET, MRI, and coronary CT angiography. A systematic search of six databases was conducted to identify studies evaluating the diagnostic accuracy of the NM 530c CZT-SPECT for detecting CAD. Comparator modalities included ICA ± FFR, PET, MRI, or coronary CTA performed within 90 days. Diagnostic performance was assessed using pooled sensitivity, specificity, summary receiver operating characteristic (SROC) curves, and diagnostic odds ratio (DOR), using R (v2024.12.0 + 467) with the "meta" and "mada" packages. A bivariate meta-analysis of 11 studies showed a pooled sensitivity of 83.5% (95% CI: 77.3-88.3%) and specificity of 75.8% (95% CI: 67.8-82.3%), with an AUC of 0.858 and diagnostic odds ratio (DOR) of 15.9. Likelihood ratios were 3.45 (positive) and 0.22 (negative). The SSS ≥ 4 subgroup showed the highest sensitivity (0.881) and DOR (19.21). The univariate random-effects model yielded a pooled sensitivity of 83% and specificity of 77%. Heterogeneity was moderate, and Deeks' test showed no publication bias (p = 0.83). This meta-analysis establishes the Discovery NM 530c CZT SPECT as a reliable and clinically effective non-invasive modality for detecting coronary artery disease (CAD), with a pooled sensitivity of 0.835, specificity of 0.758, and AUC of 0.858, supporting its diagnostic utility across diverse clinical settings.
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Registered trials
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