Evidence map›Paper›PMID 40773017›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Quantitative and simplified [18F] fluoroestradiol positron emission tomography (PET) measures of brain estrogen receptor expression.

Matilde Nerattini, Valentina Berti, Dawn C Matthews, Schantel Williams, Caroline Andy, Francesca Fauci, Camila Boneu, Trisha Ajila, Silky Pahlajani, Michael Battista and 7 more

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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Matilde NerattiniDepartment of Neurology, Weill Cornell Medicine, New York, NY, USA. matilde.nerattini@unifi.it.ORCID 0000-0002-1182-4748
Valentina BertiDepartment of Biomedical Experimental and Clinical Sciences "Mario Serio", University of Florence, Viale Morgagni, 50, Florence, 50134, FI, Italy.
Dawn C MatthewsADM Diagnostics, Northbrook, IL, USA.
Schantel WilliamsDepartment of Neurology, Weill Cornell Medicine, New York, NY, USA.
Caroline AndyDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA.
Francesca FauciDepartment of Neurology, Weill Cornell Medicine, New York, NY, USA.
Camila BoneuDepartment of Neurology, Weill Cornell Medicine, New York, NY, USA.
Trisha AjilaDepartment of Neurology, Weill Cornell Medicine, New York, NY, USA.
Silky PahlajaniDepartment of Neurology, Weill Cornell Medicine, New York, NY, USA.
Michael BattistaDepartment of Neurology, Weill Cornell Medicine, New York, NY, USA.
Randolph AndrewsADM Diagnostics, Northbrook, IL, USA.
Alberto PupiDepartment of Biomedical Experimental and Clinical Sciences "Mario Serio", University of Florence, Viale Morgagni, 50, Florence, 50134, FI, Italy.
Joseph R OsborneDepartment of Radiology, Weill Cornell Medicine, New York, NY, USA.
Matthew FinkDepartment of Neurology, Weill Cornell Medicine, New York, NY, USA.
Roberta Diaz BrintonDepartment of Pharmacology and Neurology, University of Arizona, Tucson, AZ, USA.
Jonathan P DykeDepartment of Radiology, Weill Cornell Medicine, New York, NY, USA.
Lisa MosconiDepartment of Neurology, Weill Cornell Medicine, New York, NY, USA.

Funding

Timing of Menopausal Hormone Therapy across Perimenopause to Menopause Transition: Neuroimmune System in BrainP01AG026572 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fei Yin · 2006 to 2026
$53.7M
Major Cyclotron Upgrades and RefurbishmentS10OD030447 · OD · WEILL MEDICAL COLL OF CORNELL UNIV · PI BALLON, DOUGLAS J · 2021 to 2021
$1.6M
NIA NIH HHS P01 AG026572NIH HHS S10 OD030447Wellcome Trust
6 · The paper itself

Abstract

purposePositron emission tomography (PET) with 16α-[

methodsFifty-five healthy, 40-65-year-old women at different endocrine aging stages (n = 18 premenopause, n = 18 perimenopause, and n = 19 postmenopause) underwent dynamic 90-minute

resultsSUVR measurements exhibited stronger associations with DVR at earlier compared to later time frames. Specifically, the optimal SUVR time frames in pituitary, and in most exploratory ROIs, were predominantly within the 30-50 and 40-60 min intervals. Both intervals were effective at differentiating postmenopausal versus premenopausal groups, and the 30-50 min window showed more significant associations with cognitive scores.

conclusionsExamination of quantitative and simplified methods for analysis of brain

Indexed as

BrainEstradiolPositron-Emission TomographyReceptors, EstrogenAdultAgedFemaleHumansMiddle Aged16-fluoroestradiolEstradiolReceptors, EstrogenBrainEstrogen receptorsFluoroestradiol (FES)Logan plotPositron Emission Tomography (PET)Women

Identifiers

PMID40773017
PMCPMC12830488

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.