Evidence map›Paper›PMID 40772958›Full record

ArticleJournal of proteome research2025

Mass Spectrometry-Based Analysis of Surface Proteins in

Ema Svetlicic, Leonarda A Alarcon, Roger Karlsson, Carsten Jers, Ivan Mijakovic

Abstract read
In one paragraph

Article in Journal of proteome research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ema SvetlicicNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark.ORCID 0009-0001-5062-5805
Leonarda A AlarconClinical Microbiology, Sahlgrenska University Hospital, Region Västra Götaland, 40530 Gothenburg, Sweden.
Roger KarlssonClinical Microbiology, Sahlgrenska University Hospital, Region Västra Götaland, 40530 Gothenburg, Sweden.ORCID 0000-0002-5919-2639
Carsten JersNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark.
Ivan MijakovicNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark.ORCID 0000-0002-8860-6853

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Surface proteins of Gram-positive bacteria are critical for adherence to host tissues, evasion of the immune system, and interaction with the environment. They can be utilized as biomarkers in diagnostics, for vaccine development, and as therapeutic targets due to their accessibility and role in pathogenicity. If utilized as diagnostic targets, surface biomarkers should be highly conserved across different strains of the pathogen, unique to the species to avoid cross-reactivity, abundantly expressed on the bacterial surface, and accessible to antibodies or detection reagents. Mass spectrometry-based proteomics methods have advanced the studies of surface proteins, often in combination with selective enrichment strategies such as tryptic "shaving". In this study, 11 clinical strains of

Indexed as

Bacterial ProteinsMembrane ProteinsProteomicsStaphylococcal InfectionsStaphylococcus aureusComputational BiologyHumansMass SpectrometryVirulence FactorsBacterial ProteinsMembrane ProteinsVirulence Factorsdiagnostic peptidesproteomicsStaphylococcus aureussurface proteinstryptic shaving

Identifiers

PMID40772958
PMCPMC12418492

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.