Evidence map›Paper›PMID 40772955›Full record

Observational studyAmerican journal of respiratory and critical care medicine2025

Hemodynamics and Phosphodiesterase-5 Inhibitor Treatment Associated with Survival in Pulmonary Hypertension in Interstitial Lung Disease: A PVRI GoDeep Meta-Registry Analysis.

Athiththan Yogeswaran, Paul M Hassoun, Khaled Saleh, Meike Fünderich, Aparna Balasubramanian, Ziad Konswa, David G Kiely, Allen Lawrie, Thenappan Thenappan, Christina A Eichstaedt and 32 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in American journal of respiratory and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Survival in sight: Rethinking PDE5 inhibitors in ILD-associated pulmonary hypertension.African journal of thoracic and critical care medicine · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

42 authors.

Athiththan YogeswaranDepartment of Internal Medicine, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Giessen, Germany.ORCID 0000-0001-9505-8608
Paul M HassounDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Khaled SalehCleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
Meike FünderichInstitute for Lung Health, Cardio-Pulmonary Institute, Giessen, Germany.
Aparna BalasubramanianDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-1854-6672
Ziad KonswaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
David G KielySheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, University of Sheffield and National Institute for Health and Care Research Sheffield Biomedical Research Centre, Sheffield, United Kingdom.
Allen LawrieSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, University of Sheffield and National Institute for Health and Care Research Sheffield Biomedical Research Centre, Sheffield, United Kingdom.ORCID 0000-0003-4192-9505
Thenappan ThenappanDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota.
Christina A EichstaedtGerman Center for Lung Research, Center for Pulmonary Hypertension, Thoraxklinik Heidelberg gGmbH at Heidelberg University Hospital and Translational Lung Research Center Heidelberg, Heidelberg, Germany.
Ekkehard GrünigGerman Center for Lung Research, Center for Pulmonary Hypertension, Thoraxklinik Heidelberg gGmbH at Heidelberg University Hospital and Translational Lung Research Center Heidelberg, Heidelberg, Germany.
Martin R WilkinsNational Heart and Lung Institute, Imperial College London, London, United Kingdom.ORCID 0000-0003-3926-1171
Luke HowardNational Heart and Lung Institute, Imperial College London, London, United Kingdom.ORCID 0000-0003-2822-210X
Horst OlschewskiUniversity Hospital Graz, Graz, Austria.ORCID 0000-0002-2834-7466
Gabor KovacsUniversity Hospital Graz, Graz, Austria.
Hector R CajigasDivision of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.
Robert FrantzDivision of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.
Hani SabbourCleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
Andrew J SweattDivision of Pulmonary, Allergy, and Critical Care and Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University, Stanford, California.
Roham T ZamanianDivision of Pulmonary, Allergy, and Critical Care and Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University, Stanford, California.
Alexandra Arvanitaki1st Department of Cardiology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
George Giannakoulas1st Department of Cardiology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Jean ElwingUniversity of Cincinnati, Cincinnati, Ohio.
Arun JoseUniversity of Cincinnati, Cincinnati, Ohio.
Stephan BeckmannPulmonary and Critical Care Medicine Department, Loewenstein Lung Center, Germany.
Karen M OlssonDepartment of Respiratory Medicine, Hannover Medical School, Hannover, Germany.
Stefan StadlerKlinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Regensburg, Germany.ORCID 0000-0002-8783-618X
Matthias HeldDepartment of Internal Medicine, Respiratory Medicine and Ventilatory Support, Medical Mission Hospital, Central Clinic Würzburg, Würzburg, Germany.
Michael HalankDivision of Pulmonology, Medical Department I, University Hospital Carl Gustav Carus of Technical University Dresden, Dresden, Germany.
Ralf EwertClinic of Internal Medicine, Department of Respiratory Medicine, Universitätsmedizin Greifswald, Greifswald, Germany.
Jürgen BehrDepartment of Medicine V, University Hospital, LMU Munich, Comprehensive Pneumology Center Munich, Member of the German Center for Lung Research, Munich, Germany.
Katrin Milger-KneidingerDepartment of Medicine V, University Hospital, LMU Munich, Comprehensive Pneumology Center Munich, Member of the German Center for Lung Research, Munich, Germany.
Christine PauschInnovation Center Real-World Evidence, GWT-TUD GmbH, Dresden, Germany.
David PittrowInnovation Center Real-World Evidence, GWT-TUD GmbH, Dresden, Germany.
Raphael W MajeedDepartment of Internal Medicine, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Giessen, Germany.
Jochen WilhelmDepartment of Internal Medicine, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Giessen, Germany.
Hossein Ardeschir GhofraniDepartment of Internal Medicine, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Giessen, Germany.
Friedrich GrimmingerDepartment of Internal Medicine, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Giessen, Germany.
Khodr TelloDepartment of Internal Medicine, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Giessen, Germany.
Marius M HoeperUniversity of Cincinnati, Cincinnati, Ohio.ORCID 0000-0001-9086-2293
Werner SeegerDepartment of Internal Medicine, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Giessen, Germany.
PVRI-GoDeep-Consortium

Funding

Reclassifying Pulmonary Arterial Hypertension Into Immune Phenotypes Using Machine LearningK23HL151892 · NHLBI · STANFORD UNIVERSITY · PI SWEATT, ANDREW JOHN · 2020 to 2024
$942k
Cardiovascular Medical Research and Education FundNHLBI NIH HHS K23 HL151892Pulmonary Vascular Research Institute
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

HemodynamicsHypertension, PulmonaryLung Diseases, InterstitialPhosphodiesterase 5 InhibitorsRegistriesAgedFemaleHumansMaleMiddle AgedSurvival RateVascular ResistancePhosphodiesterase 5 Inhibitorsinterstitial lung diseasepulmonary hypertensionPVRI GoDeeptreatment

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.