ArticleMicrobiology spectrum2025
Antibiotic tolerance and persistence in clinical isolates of
Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Heteroresistance tolerance and persistence in antibiotic treatment failure.Folia microbiologica · 2026Review
- Seeing Bacterial Persistence Through Different Experimental Lenses: How Methodology Shapes Biological Interpretation.Pathogens (Basel, Switzerland) · 2026Review
- Pyocyanin produced byAntimicrobial agents and chemotherapy · 2026Article
- Tail-specific protease (Tsp)-mediated envelope remodeling and beta-lactam tolerance inMicrobiology spectrum · 2026Article
- Stress History Establishes a Transient Tolerant State That Shapes Antibiotic Survival Upon Resuscitation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Beyond resistance and tolerance: rethinking evolutionary responses to antibiotics from the perspective of individual bacterial cells.Nature communications · 2026Review
- ASP-COMPLEX: redefining antimicrobial stewardship to improve outcomes in high-risk patients with severe infections.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026Review
- Deciphering the Emergence of Biofilm-Independent Colistin Persistence and Resistance inAntibiotics (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Bacteria showing tolerance to antibiotic killing are characterized by a slower kill rate compared with other isolates from the same species. Antibiotic persistence is defined by a subpopulation of bacteria showing a reduced kill rate when an isolate is exposed to a bactericidal antibiotic. Both are best studied using time-kill experiments and have been associated with treatment failure and the development of antibiotic resistance. Despite their potential clinical importance, quantitative data for the variation in antibiotic tolerance and persistence are lacking. Here, we performed time-kill experiments using 15 clinical
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.