Evidence map›Paper›PMID 40772923›Full record

ReviewJACC. Advances2025

Caring for Two: Management of the Critically Ill Cardiac Patient During Pregnancy.

Mena Gewarges, Andrew Cao, Konstantinos Alexopoulos, Maha Al-Mandhari, Filio Billia, Danielle Massarella, Marina Vainder, Candice K Silversides, Stephen E Lapinsky, Adriana C Luk

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in JACC. Advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mena GewargesDivision of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Andrew CaoDivision of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Konstantinos AlexopoulosDepartment of Anesthesia and Pain Management, University Health Network, Toronto, Ontario, Canada; Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada.
Maha Al-MandhariDepartment of Anesthesia and Pain Management, University Health Network, Toronto, Ontario, Canada; Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada.
Filio BilliaDivision of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Danielle MassarellaDivision of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada; Division of Cardiology, Miles Nadal Heart Centre, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Marina VainderDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.
Candice K SilversidesDivision of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada; Division of Cardiology, Miles Nadal Heart Centre, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Stephen E LapinskyInterdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada.
Adriana C LukDivision of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address: adriana.luk@uhn.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Critical cardiac illness in the setting of pregnancy presents a unique and complex challenge requiring multidisciplinary expertise and coordination. Physiologic changes of pregnancy can unmask or exacerbate underlying cardiac disease, placing both patient and fetus at significant risk. This review provides a comprehensive approach to the management of critically ill pregnant individuals with cardiac disease within the cardiac intensive care unit. We discuss the nuances of hemodynamic monitoring, mechanical ventilation strategies, and pharmacotherapy tailored to the pregnant state. Special emphasis is placed on cardiac arrest management, as well as the diagnosis and treatment of acute cardiac conditions such as acute coronary syndromes, heart failure, cardiogenic shock, and valvular heart disease. Practical considerations for fetal monitoring, delivery planning, and postpartum care are also highlighted. This review aims to equip cardiac intensivists, obstetricians, anesthesiologists, and maternal-fetal medicine specialists with evidence-based strategies to optimize outcomes for both pregnant individual and fetus.

Indexed as

acute coronary syndromecardiac arrestcardiac critical careheart failurepregnancyvalvular disease

Identifiers

PMID40772923
PMCPMC12541215

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.