Evidence map›Paper›PMID 40772826›Full record

ArticleAntimicrobial agents and chemotherapy2025

New derivatives of 6-nitrocoumarin-3-thiosemicarbazone exhibit improved antiparasitic activity in the placenta against

Esteban Rocha-Valderrama, Santiago Rostán, Mercedes Fernández, Ana Liempi, Christian Castillo, Graciela Mahler, Ambar Galarza-Jarrin, Jaime A Costales, Josué Pozo-Martínez, Claudio Olea-Azar and 2 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Esteban Rocha-Valderrama *Instituto Universitario de Investigación y Desarrollo Tecnológico, Universidad Tecnológica Metropolitana, Santiago, Chile.
Santiago Rostán *Área Química Inorgánica, DEC, Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Mercedes FernándezÁrea Química Inorgánica, DEC, Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Ana LiempiPrograma de Biología Integrativa, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Christian CastilloPrograma de Biología Integrativa, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Graciela MahlerDepartamento de Química Orgánica, Laboratorio de Química Farmacéutica, Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Ambar Galarza-JarrinCentro de Investigación para la Salud en América Latina, Pontificia Universidad Católica del Ecuador, Quito, Pichincha, Ecuador.
Jaime A CostalesCentro de Investigación para la Salud en América Latina, Pontificia Universidad Católica del Ecuador, Quito, Pichincha, Ecuador.ORCID 0000-0001-9418-6640
Josué Pozo-MartínezCentro de Investigación para la Salud en América Latina, Pontificia Universidad Católica del Ecuador, Quito, Pichincha, Ecuador.
Claudio Olea-AzarInorganic and Analytical Department, Free Radical and Antioxidants Laboratory, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile.
Lucía OteroÁrea Química Inorgánica, DEC, Facultad de Química, Universidad de la República, Montevideo, Uruguay.ORCID 0000-0002-3569-1660
Mauricio Moncada-BasualtoInstituto Universitario de Investigación y Desarrollo Tecnológico, Universidad Tecnológica Metropolitana, Santiago, Chile.ORCID 0000-0003-1733-9126

Funding

Agencia Nacional de Investigacion y Desarrollo, ANID 11220310Agencia Nacional de Investigacion y Desarrollo, ANID 11240973Agencia Nacional de Investigacion y Desarrollo, ANID 1230644Agencia Nacional de Investigacion y Desarrollo, ANID 3230385Agencia Nacional de Investigacion y Desarrollo, ANID EQM230118Competition for Research Regular Projects LPR22-01Pontificia Universidad Católica del Ecuador QINV0416-IINV529010300
6 · The paper itself

Abstract

Congenital infections by

Indexed as

Antiparasitic AgentsCoumarinsPlacentaThiosemicarbazonesToxoplasmaTrypanosoma cruziChagas DiseaseFemaleHumansParasitic Sensitivity TestsPregnancyStructure-Activity RelationshipToxoplasmosisAntiparasitic AgentsCoumarinsThiosemicarbazones6-nitrocoumarin-3-thiosemicarbazonein vitro and ex vivo modelsToxoplasma gondiiTrypanosoma cruzi

Identifiers

PMID40772826
PMCPMC12406664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.