Evidence map›Paper›PMID 40772817›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2025

Circular RNA Profiling Identifies

M Martin VandenBroek, Mackenzie C Sharp, Patrick Thompson, Emmanuel Fagbola, Douglas Quilty, Jeffrey D Mewburn, Anne L Theilmann, Kimberly J Dunham-Snary, Anna R Hemnes, Joy D Cogan and 5 more

Abstract read
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The Role of Stress Granules in Cardiovascular Diseases.Reviews in cardiovascular medicine · 2026
    Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

M Martin VandenBroekDepartment of Medicine (M.M.V., E.F., J.D.M., S.L.A., M.L.O.), Queen's University, Kingston, ON, Canada.ORCID 0000-0003-4937-2502
Mackenzie C SharpQueen's University School of Computing, Kingston, ON, Canada (M.C.S.).
Patrick ThompsonDepartments of Biomedical and Molecular Sciences and Surgery (P.T., D.Q., A.L.T., K.J.D.-S., M.L.O.), Queen's University, Kingston, ON, Canada.ORCID 0009-0003-3955-3235
Emmanuel FagbolaDepartment of Medicine (M.M.V., E.F., J.D.M., S.L.A., M.L.O.), Queen's University, Kingston, ON, Canada.
Douglas QuiltyDepartments of Biomedical and Molecular Sciences and Surgery (P.T., D.Q., A.L.T., K.J.D.-S., M.L.O.), Queen's University, Kingston, ON, Canada.ORCID 0000-0002-3020-4210
Jeffrey D MewburnDepartment of Medicine (M.M.V., E.F., J.D.M., S.L.A., M.L.O.), Queen's University, Kingston, ON, Canada.ORCID 0000-0002-1365-4228
Anne L TheilmannDepartments of Biomedical and Molecular Sciences and Surgery (P.T., D.Q., A.L.T., K.J.D.-S., M.L.O.), Queen's University, Kingston, ON, Canada.ORCID 0000-0003-3051-3096
Kimberly J Dunham-SnaryDepartments of Biomedical and Molecular Sciences and Surgery (P.T., D.Q., A.L.T., K.J.D.-S., M.L.O.), Queen's University, Kingston, ON, Canada.ORCID 0000-0001-9760-342X
Anna R HemnesVanderbilt University Medical Center, Nashville, TN (A.R.H., J.D.C., E.D.A., R.H.).ORCID 0000-0002-2755-5845
Joy D CoganVanderbilt University Medical Center, Nashville, TN (A.R.H., J.D.C., E.D.A., R.H.).
Eric D AustinVanderbilt University Medical Center, Nashville, TN (A.R.H., J.D.C., E.D.A., R.H.).ORCID 0000-0002-1709-9022
Rizwan HamidVanderbilt University Medical Center, Nashville, TN (A.R.H., J.D.C., E.D.A., R.H.).ORCID 0000-0001-5063-7614
Stephen L ArcherDepartment of Medicine (M.M.V., E.F., J.D.M., S.L.A., M.L.O.), Queen's University, Kingston, ON, Canada.ORCID 0000-0003-1106-3202
Neil RenwickDepartment of Pathology and Molecular Medicine (N.R.), Queen's University, Kingston, ON, Canada.ORCID 0000-0001-6695-8236
Mark L OrmistonDepartment of Medicine (M.M.V., E.F., J.D.M., S.L.A., M.L.O.), Queen's University, Kingston, ON, Canada.ORCID 0000-0003-0907-1940

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe

methodsCircular RNAs were profiled by ultradeep RNA sequencing of human pulmonary artery endothelial cells. Novel

resultsDepletion of

conclusionsThe identification of

Indexed as

Bone Morphogenetic Protein Receptors, Type IICell ProliferationEndothelial CellsPulmonary Arterial HypertensionPulmonary ArteryRNA, CircularApoptosisCell Cycle ProteinsCells, CulturedHumansMaleSignal TransductionBMPR2 protein, humanBone Morphogenetic Protein Receptors, Type IICell Cycle ProteinsRNA, Circularendothelial cellsphosphorylationpulmonary arterial hypertensionRNA, circularstress granules

Identifiers

PMID40772817
PMCPMC12379793

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.