Evidence map›Paper›PMID 40772778›Full record

ArticleStatistics in medicine2025

Constructing a T-Test for Value Function Comparison of Individualized Treatment Regimes in the Presence of Multiple Imputation for Missing Data.

Minxin Lu, Annie Green Howard, Penny Gordon-Larsen, Katie A Meyer, Hsiao-Chuan Tien, Shufa Du, Huijun Wang, Bing Zhang, Michael R Kosorok

Abstract readComparative Study
In one paragraph

Article in Statistics in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Minxin LuDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Annie Green HowardDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Penny Gordon-LarsenCarolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Katie A MeyerDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Hsiao-Chuan TienCarolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Shufa DuCarolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Huijun WangNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, China.
Bing ZhangNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, China.
Michael R KosorokDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Funding

North Carolina Translational and Clinical Sciences Institute (NC TraCS)UM1TR004406 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NICHOLAS J SHAHEEN · 2023 to 2026
$37.5M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
MONITORING SOCIAL CHANGE: HEALTH, REPRODUCTION, AGINGR01HD030880 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ADAIR, LINDA S, POPKIN, BARRY M · 1994 to 2024
$27.0M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
Program Development (Pilot) CoreP30AG066615 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TAYLOR HARGROVE · 2020 to 2026
$4.1M
Monitoring Social Change: Dynamics Of Aging And Cognitive FunctionR01AG065357 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ADAIR, LINDA S, POPKIN, BARRY M · 2020 to 2024
$3.6M
Emergence of Cardiometabolic Risk Across the Lifecycle in ChinaR01HL108427 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GORDON-LARSEN, PENNY · 2012 to 2015
$2.7M
Transition to a Western diet and cardiometabolic risk: biomarkers derived from the microbiomeR01DK104371 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GORDON-LARSEN, PENNY · 2015 to 2018
$2.5M
CHILD HEALTH EFFECTS OF RAPID SOCIO-DEMOGRAPHIC CHANGER01HD038700 · NICHD · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI POPKIN, BARRY M · 2000 to 2004
$1.5M
Nutrition-Related NCD Prevention Training in ChinaD43TW009077 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI POPKIN, BARRY M · 2011 to 2015
$1.1M
FIC NIH HHS D43 TW009077NCATS NIH HHS UM1 TR004406NHLBI NIH HHS R01 HL108427NIA NIH HHS P30 AG066615NIA NIH HHS R01 AG065357NICHD NIH HHS P2C HD050924NICHD NIH HHS R01 HD030880NICHD NIH HHS R01 HD038700NIDDK NIH HHS P30 DK056350NIDDK NIH HHS R01 DK104371NIH HHS D43 TW009077NIH HHS P2C HD050924NIH HHS P30 AG066615NIH HHS P30 DK056350NIH HHS R01 AG065357NIH HHS R01 DK104371NIH HHS R01 HD30880NIH HHS R01 HD38700NIH HHS R01 HL108427NIH HHS UM1 TR004406
6 · The paper itself

Abstract

Optimal individualized treatment decision-making has improved health outcomes in recent years. The value function is commonly used to evaluate the goodness of an individualized treatment decision rule. Despite recent advances, comparing value functions between different treatment decision rules or constructing confidence intervals around value functions remains difficult. We propose a t-test based method applied to a test set that generates valid p-values to compare value functions between a given pair of treatment decision rules when some of the data are missing. We demonstrate the ease in use of this method and evaluate its performance via simulation studies and apply it to the China Health and Nutrition Survey data.

Indexed as

Precision MedicineChinaComputer SimulationConfidence IntervalsData Interpretation, StatisticalHumansModels, StatisticalNutrition Surveysimputationindividualized treatment regimesprecision medicinet‐testvalue function

Identifiers

PMID40772778
PMCPMC12333556

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.