ArticlemBio2025
Paired single-cell and spatial transcriptional profiling reveals a central osteopontin macrophage response mediating tuberculous granuloma formation.
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Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
What it found
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Who cites it
13 citing papers in PubMed.
- Host eicosanoid signals define a granuloma fibroblast population that coordinates mycobacterial containment.Cell host & microbe · 2026Article
- The Kynurenine Pathway in Tuberculosis: Focus on Immunometabolic Regulation, Compartment-Specific Biology, and Therapeutic Potential.Life (Basel, Switzerland) · 2026Review
- γδ T Cells at the Crossroads of Tuberculosis and COPD: From Early Immunity to Tissue Remodeling.International journal of molecular sciences · 2026Review
- Clinical Utility of Pleural Tissue Debris Incidentally Obtained During Drainage of Pleural Effusion: A Retrospective Cohort Study.Biomedicines · 2026Article
- Impaired IFNγ responsiveness of monocyte-derived lung cells limits immunity to Mycobacterium tuberculosis.Nature communications · 2026Article
- Alternatively activated monocyte-derived myeloid cells promote extracellular pathogen persistence in pulmonary fungal granulomas.The Journal of experimental medicine · 2026Article
- CCR6 is essential for effective immunity againstInfection and immunity · 2026Article
- Advances in Spatial Transcriptomics for Infectious Disease Research: Insight for Vaccine Development.Vaccines · 2026Review
- Granuloma dual RNA-seq reveals composite transcriptional programs driven by neutrophils and necrosis within tuberculous granulomas.Science advances · 2026Article
- Spatial mapping of Ethiopian cutaneous leishmaniasis lesions reveals distinct tissue level immune programs.Frontiers in immunology · 2026Article
- Vγ9Vδ2 T cells in tuberculosis: protective immunity and translational perspectives.Frontiers in immunology · 2026Review
- The role and mechanisms of multiple immunoregulatory cells in pulmonary tuberculosis.Frontiers in immunology · 2026Review
- Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity.PLoS biology · 2025Article
Corrections and comments
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Authors and funding
14 authors.
Charlie J PyleDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-6355-0638
Liuyang WangDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
Rebecca W BeermanDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
Vaibhav JainDuke Molecular Physiology Institute, Duke University, Durham, North Carolina, USA.
Henry K E OhmanDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
Brandon A ThompsonDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
Karen R AbramsonDuke Molecular Physiology Institute, Duke University, Durham, North Carolina, USA.
Dennis C KoDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-0113-5981
Simon G GregoryDuke Molecular Physiology Institute, Duke University, Durham, North Carolina, USA.
Clare M SmithDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0003-2601-0955
Jadee L NeffDepartment of Pathology, Duke University School of Medicine, Durham, North Carolina, USA.
Rebecca J RichardsonSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom.
Jason E StoutDepartment of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA.
David M TobinDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0003-3465-5518
Funding
Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI Laura Fish · 1985 to 2026
$174.8MSocial and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5MRuth L. Kirschstein National Research Service Award (NRSA)- T32T32AI007392 · NIAID · DUKE UNIVERSITY · PI Amy Lynn Corneli, Guido Ferrari · 1990 to 2026
$9.8MMacrophage Reprogramming During Granuloma Formation in the ZebrafishR01AI130236 · NIAID · DUKE UNIVERSITY · PI David M. Tobin · 2017 to 2026
$4.5MGenetic dissection of angiogenesis in the tuberculous granulomaR01AI125517 · NIAID · DUKE UNIVERSITY · PI David M. Tobin · 2017 to 2026
$4.4MNRSA Training CoreTL1TR002555 · NCATS · DUKE UNIVERSITY · PI EDELMAN, DAVID · 2018 to 2022
$3.7MLinking Human TB Genetic Susceptibility Loci to Granuloma BiologyR01AI166304 · NIAID · DUKE UNIVERSITY · PI David M. Tobin · 2022 to 2026
$3.4MThe Genetic Basis of Bone Disease in Mycobacterial InfectionR01AI127715 · NIAID · DUKE UNIVERSITY · PI Clare Margaret Smith, David M. Tobin · 2017 to 2026
$3.3MBritish Heart Foundation PG/21/10646National Institute of Allergy and Infectious Diseases 5P30 AI064518National Institute of Allergy and Infectious Diseases AI125517, AI127715, AI130236, AI166304NCATS NIH HHS TL1 TR002555NCI NIH HHS P30 CA014236NIAID NIH HHS P30 AI064518NIAID NIH HHS R01 AI125517NIAID NIH HHS R01 AI127715NIAID NIH HHS R01 AI130236NIAID NIH HHS R01 AI166304NIAID NIH HHS T32 AI007392NIH HHS P30CA014236
Abstract
Granulomas are classic manifestations of tuberculosis pathogenesis. They result from an ensemble of immune responses to
Indexed as
GranulomaMacrophagesOsteopontinTuberculosisAnimalsGene Expression ProfilingHumansMycobacterium marinumMycobacterium tuberculosisSingle-Cell AnalysisOsteopontinSPP1 protein, humangranulomamacrophageMycobacterium tuberculosisosteopontinscRNA-seqspatial transcriptomicsspp1tuberculosis
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.