Evidence map›Paper›PMID 40772760›Full record

ArticlemBio2025

Structure of the T9SS PorKN ring complex reveals conformational plasticity based on the repurposed FGE fold.

Xiangan Liu, John D Perpich, Liqiang Song, Christian Cambillau, Thierry Doan, Lei Zheng, Richard J Lamont, Eric Cascales, Bo Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiangan LiuDepartment of Microbiology and Molecular Genetics, McGovern Medical School, Houston, Texas, USA.
John D PerpichDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, Kentucky, USA.
Liqiang SongDepartment of Microbiology and Molecular Genetics, McGovern Medical School, Houston, Texas, USA.
Christian CambillauLaboratoire d'Ingénierie des Systèmes Macromoléculaires (LISM, UMR7255), Aix-Marseille Université, CNRS, Marseille, France.ORCID 0000-0001-5502-4729
Thierry DoanLaboratoire d'Ingénierie des Systèmes Macromoléculaires (LISM, UMR7255), Aix-Marseille Université, CNRS, Marseille, France.
Lei ZhengDepartment of Biochemistry, McGovern Medical School, Houston, Texas, USA.
Richard J LamontDepartment of Oral Immunology and Infectious Diseases, University of Louisville, Louisville, Kentucky, USA.ORCID 0000-0002-3147-5039
Eric CascalesLaboratoire d'Ingénierie des Systèmes Macromoléculaires (LISM, UMR7255), Aix-Marseille Université, CNRS, Marseille, France.ORCID 0000-0003-0611-9179
Bo HuDepartment of Microbiology and Molecular Genetics, McGovern Medical School, Houston, Texas, USA.ORCID 0000-0002-9117-879X

Funding

In Situ Architecture of Specialized Bacterial Secretion SystemsR35GM138301 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HU, BO · 2020 to 2024
$2.0M
Structure and Function of Porphyromonas gingivalis Type IX Secretion SystemR01DE033452 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Bo Hu, Richard J Lamont · 2024 to 2026
$1.2M
Agence Nationale de la Recherche ANR-15-CE11-0019,ANR-20-CE11-0011A*Midex A-M-AAP-ID-17-33-170301-07.22Fondation pour la Recherche Médicale EQU202403018010NIDCR NIH HHS R01 DE033452NIDCR NIH HHS R01DE033452NIGMS NIH HHS R35 GM138301NIGMS NIH HHS R35GM138301
6 · The paper itself

Abstract

The type IX secretion system (T9SS) is a protein secretion machinery unique to the Bacteroidetes-Chlorobi-Fibrobacteres superphylum, which plays crucial roles in bacterial pathogenesis and gliding motility. It is composed of >15 proteins, including the proton-motive force-dependent PorLM motor, the PorKN ring anchored to the outer membrane, and the Sov translocon. Here, we present the cryo-electron microscopy (EM) structure of the PorKN ring complex from

Indexed as

Bacterial ProteinsBacterial Secretion SystemsPorphyromonas gingivalisCryoelectron MicroscopyModels, MolecularProtein ConformationProtein FoldingBacterial ProteinsBacterial Secretion Systemscryo-EMsurface structurestype 9 protein secretion

Identifiers

PMID40772760
PMCPMC12421860

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.