ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2026
Single-cell sequencing reveals potential novel insights into appendage-patterning and joint-development in a spider.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Editorial highlights.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Developmental system drift in the patterning of the arthropod tarsus.Proceedings. Biological sciences · 2026Article
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3 authors.
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Abstract
backgroundJointed appendages represent one of the key innovations of arthropods, and thus understanding the development and evolution of these structures is important for the understanding of the evolutionary success of Arthropoda. In this paper, we analyze a cell cluster that was identified in a previous single-cell sequencing (SCS) experiment on embryos of the spider Parasteatoda tepidariorum. This cell cluster is characterized by marker genes that suggest a role in appendage patterning and joint development.
resultsWe analyzed the expression profiles of these marker genes showing that they are expressed in the developing appendages and in a pattern that suggests a potential function during joint development. Several of the investigated genes represent new and unexpected factors such as dysfusion (dysf), spätzle3 (spz3), seven-up (svp). In order to study their evolutionary origin, we also investigated orthologs of the identified appendage-patterning genes in the harvestman Phalangium opilio, a distantly related chelicerate.
conclusionOur work highlights the usefulness of SCS experiments for the identification of potential new genetic factors that are involved in specific developmental processes. The current data provide potential new insights into the gene regulatory networks that underlie arthropod joint development.
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