Evidence map›Paper›PMID 40772524›Full record

Trial reportCancer2025

Factors influencing engagement with patient-directed and facilitated advance care planning interventions for patients with advanced cancer.

Kimberly J Rak, Renusha Indralingam, Aaron Richardson, Neha Dhole, Shane Belin, Monica C Leon Cadavid, Yuxin Zhou, Georgeann Booth, Bernard Hammes, Betty Ferrell and 5 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kimberly J RakDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-5769-3301
Renusha IndralingamDepartment of Family Medicine, Brown University, Providence, Rhode Island, USA.
Aaron RichardsonDepartment of Medicine, West Virginia School of Medicine, Morgantown, West Virginia, USA.
Neha DholePublic Health Foundation of India, New Delhi, India.ORCID https://orcid.org/0009-0005-8092-3757
Shane BelinDivision of General Internal Medicine, Section of Palliative Care and Medical Ethics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Monica C Leon CadavidDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Yuxin ZhouDepartment of Nursing, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.ORCID https://orcid.org/0000-0002-6421-5647
Georgeann BoothSchool of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Bernard HammesRespecting Choices, La Crosse, Wisconsin, USA.
Betty FerrellCity of Hope Medical Center, Los Angeles, California, USA.ORCID https://orcid.org/0000-0003-0061-5235
Douglas B WhiteDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Robert M ArnoldDepartment of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Rebecca L SudoreDivision of Geriatrics, Department of Medicine, University of California, San Francisco, California, USA.
Megan Crowley-MatokaFeinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Yael SchenkerDivision of General Internal Medicine, Section of Palliative Care and Medical Ethics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0M
Patient-centered and efficacious advance care planning in cancer: the PEACe comparative effectiveness trialR01CA235730 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCHENKER, YAEL · 2019 to 2024
$3.1M
Mentoring Researchers in Advance Care Planning for Underrepresented Older Adults at Risk for Alzheimer’s Disease and Related Dementias and Their CaregiversK24AG054415 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REBECCA L SUDORE · 2017 to 2026
$1.7M
Mentored Patient Oriented Research in Improving Surrogate Decision Making for Patients with Advanced Respiratory FailureK24HL148314 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Douglas B White · 2019 to 2026
$944k
Midcareer Investigator Award in Patient-Oriented Research: Yael Schenker, MD, MASK24AG070285 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCHENKER, YAEL · 2021 to 2025
$841k
NCI NIH HHS P30 CA047904NCI NIH HHS P30CA047904NCI NIH HHS R01 CA235730NCI NIH HHS R01CA235730NHLBI NIH HHS K24 HL148314NHLBI NIH HHS K24HL148314NIA NIH HHS K24 AG054415NIA NIH HHS K24AG054415NIA NIH HHS K24 AG070285NIA NIH HHS K24AG070285
6 · The paper itself

Abstract

backgroundAdvance care planning (ACP) for patients with cancer is guideline recommended. However, there are significant challenges to engagement. Patient-facing ACP programs have been developed to improve access and engagement. This study aimed to identify factors impacting engagement for patients with cancer generally, and specifically for two patient-facing approaches.

methodsAs part of a randomized trial comparing the effectiveness of facilitated versus patient-directed ACP, interviews were conducted with patients with cancer who participated in the two interventions. A thematic analysis approach was used, iteratively reviewing transcripts to identify and group concepts into themes.

resultsBetween 2020 and 2023, 60 participants in the parent study were interviewed (31 facilitated and 29 patient-directed). Several themes were identified that contributed to ACP engagement, including a realist attitude, increased skills from previous ACP, and motivational beliefs such as alleviating burden for loved ones. Features of ACP design that facilitated engagement included intellectualization and normalization of content. For facilitated ACP, patients valued the interpersonal exchange with the interventionist. For patient-directed ACP, participants appreciated the ability to step away and come back to the website. Participants discussed how ACP needs to be an iterative process as people have varying capacity or motivation to engage at different timepoints.

conclusionsMany patients with cancer are motivated to engage in ACP to decrease burden on others and receive patient-centered care. A constellation of factors interact as facilitators or barriers to engagement. Therefore, a one-time, one-size approach is not recommended; facilitating engagement may require flexible approaches offered at multiple time points.

Indexed as

Advance Care PlanningNeoplasmsPatient ParticipationAdultAgedFemaleHumansMaleMiddle AgedMotivationadvance care planningcomparative effectiveness researchpatient‐centered carepatient engagementqualitative research

Identifiers

PMID40772524
PMCPMC12329779

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.