ArticleGlia2025
Unraveling the Role of Ensheathing Cells and Perineural Fibroblasts in Olfactory Neurogenesis.
Article in Glia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
During development and following injury-induced neurogenesis, olfactory ensheathing cells (OECs) envelope the axon bundles of sensory neurons and support their growth to the glomerular destinations in the olfactory bulb. Transplantation of OECs to various neuronal injury locations showed a reparative impact; however, there was huge variability. By combining mRNA sequencing with bioinformatics analysis and immunohistochemistry, we characterized the cellular and molecular biological properties of OECs of the lamina propria and their response to neuronal injury. We found that OECs do not express NGFR (p75) under steady state conditions, questioning the common approach of isolating OECs with NGFR antibodies. While OECs express a peculiar combination of markers of different types of glial cells, they are strikingly similar to satellite glia cells of the dorsal root ganglion; for example, they showed marked upregulation of genes involved in lipid metabolism during neuronal regeneration. Similar to satellite glia cells and unlike Schwann cells, adult OECs did not proliferate in response to injury. Like endothelial cells at the blood-brain barrier and unlike other glia types, OECs showed extensive connections via the tight junction protein Claudin 5. Furthermore, OECs lack water channels, which probably explains why they sustain a stable environment after olfactory epithelium ablation. Regulation of the extracellular osmolarity seems to involve Aquaporin 1 in perineural fibroblasts together with high levels of KCNJ10, Na
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.