Dysphagia in Huntington's Disease: An Evaluation of Swallowing Disturbance across the HD-ISS Staging Spectrum.

Japleen Kaur, Krisha Bagga, Paul E Gilbert, Jody Corey-Bloom

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Article in Movement disorders clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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4 authors.

Japleen KaurNeurosciences, University of California San Diego, San Diego, California, USA.ORCID https://orcid.org/0009-0006-6553-0944

Krisha BaggaNeurosciences, University of California San Diego, San Diego, California, USA.ORCID https://orcid.org/0009-0006-6438-1844

Paul E GilbertDepartment of Psychology, San Diego State University, San Diego, California, USA.

Jody Corey-BloomNeurosciences, University of California San Diego, San Diego, California, USA.ORCID https://orcid.org/0000-0001-9790-8610

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe onset and pattern of progression of swallowing impairment in HD remain poorly understood. The Swallowing Disturbance Questionnaire (SDQ) has proven useful in assessing dysphagia across various neurological conditions, but its use in HD remains largely unexplored.

objectivesTo evaluate swallowing difficulties in HD using the SDQ and Huntington's Disease Integrated Staging System.

methodsThe SDQ was administered to 87 gene positive subjects stratified into HD-ISS Stages 0/1 (n = 27), 2 (n = 21), and 3 (n = 39). Kruskal-Wallis was used to compare performance among cohorts and partial eta-squared (η

resultsTotal swallowing disturbance score significantly differed across HD-ISS stages (ηp

conclusionsSwallowing disturbances emerge early and progressively worsen across the HD-ISS staging spectrum, with both oral and pharyngeal phases affected. These findings suggest that early assessment of swallowing function is warranted in HD clinical care.

Indexed as

Deglutition DisordersHuntington DiseaseAdultAgedDisease ProgressionFemaleHumansMaleMiddle AgedSeverity of Illness IndexSurveys and QuestionnairesdysphagiaHD‐ISS staging systemHuntington's diseaseswallowing impairment

Identifiers

PMID40772438

DOI10.1002/mdc3.70271

PMCPMC12715338

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