ArticleSmall (Weinheim an der Bergstrasse, Germany)2025
Surface-Engineering of Pancreatic Islets with Chitosan Microparticles to Inhibit IBMIR in Islet Xenotransplantation.
Article in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Review
- Surface-Engineering of Pancreatic Islets with Chitosan Microparticles to Inhibit IBMIR in Islet Xenotransplantation.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Xenotransplantation Literature Update: July-December 2025.XenotransplantationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Intraportal islet transplantation is an effective beta-cell replacement therapy for restoring insulin production in patients with type 1 diabetes. However, transplanted islets are rapidly lost due to a strong immediate inflammatory reaction, termed as instant blood-mediated inflammatory reaction (IBMIR). Current preventive therapies for IBMIR face systemic side effects such as bleeding risks. Although surface islet modification with biocompatible polymers or antithrombotic molecules shows promise, the limited anchoring of these molecules on the islet surface, caused by low conjugation efficiency and complex procedures in current methods, often lead to suboptimal outcomes. In this study, a novel islet conjugation platform is presented for effectively delivering heparin (HEP) for overcoming IBMIR. The islet surface is first conjugated with chitosan microparticles (CSMP) via electrostatic interaction. HEP is then absorbed into the conjugated CSMP with a high amount (4.4 ng IEQ
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.