Evidence map›Paper›PMID 40772290›Full record

ArticleRenal failure2025

Factors associated with successful transition from continuous renal replacement therapy in critically ill patients: a retrospective cohort study.

Ronald Miller, Abdel-Rauof Akkari, Ahmad Matarneh, Fareeha Khalil, Paddy Ssentongo, Sundus Sardar, Rafael Portela Colon, Mohammad Gul Khan, Yousif Rajab, Maaz Ali and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Ronald MillerDivision of Nephrology, Department of Medicine, Penn State Health, Milton S. Hershey Medical Center, Hershey, PA, USA.
Abdel-Rauof AkkariDivision of Nephrology, Department of Medicine, Penn State Health, Milton S. Hershey Medical Center, Hershey, PA, USA.
Ahmad MatarnehDivision of Nephrology, Department of Medicine, Penn State Health, Milton S. Hershey Medical Center, Hershey, PA, USA.
Fareeha KhalilDivision of Nephrology, Department of Medicine, Penn State Health, Milton S. Hershey Medical Center, Hershey, PA, USA.
Paddy SsentongoDivision of Infectious Diseases, Penn State Health, Milton S. Hershey Medical Center, Hershey, PA, USA.
Sundus SardarDivision of Nephrology, Department of Medicine, Penn State Health, Milton S. Hershey Medical Center, Hershey, PA, USA.
Rafael Portela ColonDivision of Nephrology, Department of Medicine, Penn State Health, Milton S. Hershey Medical Center, Hershey, PA, USA.
Mohammad Gul KhanDivision of Nephrology, Department of Medicine, Penn State Health, Milton S. Hershey Medical Center, Hershey, PA, USA.
Yousif RajabDepartment of Internal Medicine, Penn State Health, Milton S. Hershey Medical Center, Hershey, PA, USA.
Maaz AliPenn State College of Medicine, Hershey, PA, USA.
Nadia ObaedDepartment of Internal Medicine, Penn State Health, Milton S. Hershey Medical Center, Hershey, PA, USA.
Samyukta KarthikPenn State College of Medicine, Hershey, PA, USA.
Medha PrabhuPenn State College of Medicine, Hershey, PA, USA.
Julio HernandezDepartment of Internal Medicine, Penn State Health, Milton S. Hershey Medical Center, Hershey, PA, USA.
Yash PatelPenn State College of Medicine, Hershey, PA, USA.
Mujahed DaulehCenter for Kidney Disease and Hypertension, Wormleysburg, PA, USA.
Grace HwangPenn State College of Medicine, Hershey, PA, USA.
Gianni PescettoPenn State College of Medicine, Hershey, PA, USA.
Nasrollah GhahramaniDivision of Nephrology, Department of Medicine, Penn State Health, Milton S. Hershey Medical Center, Hershey, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute kidney injury (AKI) in critically ill patients often requires continuous renal replacement therapy (CRRT), yet predictors of successful transition off CRRT remain unclear. This study aimed to identify clinical factors associated with successful and sustained CRRT discontinuation.

methodsWe retrospectively analyzed 924 adult ICU patients who received CRRT between January 2010 and December 2024. The primary outcome was successful CRRT transition, defined as discontinuation without CRRT re-initiation within 7 days or transition to intermittent hemodialysis. Multivariable logistic regression was used to evaluate associations with clinical, hemodynamic, and biochemical parameters.

resultsOf 924 patients (mean age 60 ± 14 years; 66% male), 823 (89%) successfully transitioned off CRRT. Vasopressor use (adjusted odds ratio [aOR] 0.68,

conclusionHigher urine output, better acid-base status, and stable hemodynamics predict successful and sustained CRRT discontinuation. Ongoing vasopressor use and high fluid burden reduce the likelihood of success.

Indexed as

Acute Kidney InjuryContinuous Renal Replacement TherapyAgedBlood Urea NitrogenCritical IllnessFemaleHumansIntensive Care UnitsLogistic ModelsMaleMiddle AgedRespiration, ArtificialRetrospective StudiesTreatment OutcomeVasoconstrictor AgentsVasoconstrictor Agentsacute kidney injuryContinuous renal replacement therapycritical care nephrologydialysis transitionintermittent hemodialysisrenal recovery

Identifiers

PMID40772290
PMCPMC12332985

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.