Evidence map›Paper›PMID 40772206›Full record

ArticleCureus2025

Concurrent Metastatic Clear Cell Renal Cell Carcinoma and Chronic Lymphocytic Leukemia Within the Same Lymph Node: A Case Report and Review of Dual Malignancy Management.

Paul F Hanona, Morgan Kiryakoza, Ping Zhang, George Howard

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Paul F HanonaHematology Oncology, Corewell Health East, Royal Oak, USA.
Morgan KiryakozaHematology Oncology, Corewell Health East, Royal Oak, USA.
Ping ZhangPathology, Corewell Health East, Royal Oak, USA.
George HowardOncology, Corewell Health East, Royal Oak, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dual malignancies involving clear cell renal cell carcinoma (ccRCC) and chronic lymphocytic leukemia (CLL) present a rare and challenging clinical scenario. This report describes a 75-year-old male with a history of monoclonal B-cell lymphocytosis (MBL) that progressed to CLL, later complicated by the development of ccRCC. Following neoadjuvant pembrolizumab, he underwent left nephrectomy with pathology confirming renal cell carcinoma (RCC). Subsequent imaging revealed a recurrent renal bed nodule, and a retroperitoneal lymph node biopsy demonstrated concurrent CLL and metastatic RCC. Our report aims to enhance recognition and management strategies for such complex dual malignancies.

Indexed as

chronic lymphocytic leukemiacllimmunotherapypembrolizumabrccrenal cell carcinomaurology

Identifiers

PMID40772206
PMCPMC12327551

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.