ArticleJournal of education and health promotion2025
The relationship between the maternal consumption of barberry, saffron, pickled vegetables, and tea and the odds of congenital anomalies in Iranian children under 10 years of age: A case-control study.
Article in Journal of education and health promotion, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe administration of barberry extract and saffron to pregnant mice has been reported to cause abnormalities in fetus development. Given the high cultivation of barberry and saffron in Qayenat, we aimed to investigate the association of the maternal use of barberry, saffron, pickled vegetables, and tea during gestation with Congenital Anomalies (CA) in Qayenat City, South Khorasan Province. METHODS AND MATERIALS: The present case-control study was done on 150 patients under 10 years of age with CA (case group) and 150 healthy children that were selected for each case, with the same age (±2 months) and sex, from the same town (control group) between March and May 2023. In this study, participants were included using convenient sampling in a consecutive manner. To control the possible confounding factors, and to identify independent risk factors for CA, multivariate logistic regression, adjusted odds ratios (ORs), and 95% confidence intervals (CIs) were carried out for this study.
resultsMore than 3 times pickled vegetable consumption in the week was also associated with an increased risk of CA (OR = 5.09; 95% CI: 1.66-15.55). More daily intake of barberry (more than a tablespoon) was associated with higher odds of CA (OR = 9.23; 95% CI: 3.42-24.90). There was no significant association between CA and daily intake of saffron (
conclusionsIn the present study, we found that maternal use of barberry, pickled vegetables, and tea during pregnancy were positively related to the odds of CA. Further detailed studies to determine the teratogenicity mechanism of these factors are recommended.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.