ArticleCureus2025
Outcomes, Predictors of Retreatment, and Complications After Repeat Gamma Knife Radiosurgery for Trigeminal Neuralgia: A Single-Center Retrospective Cohort Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Repeat gamma knife radiosurgery for recurrent trigeminal neuralgia: a systematic review and meta-analysis.Acta neurochirurgica · 2026Pooled it
- V1-dominant Recurrence of Trigeminal Neuralgia after Gamma Knife Radiosurgery for V2-V3 Pain in a Patient with Persistent Vertebral Artery Compression: A Case Report.NMC case report journal · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study was conducted to evaluate the outcomes of repeat Gamma Knife surgery (GKS) in patients with recurrent trigeminal neuralgia (TN), identify predictors for retreatment, and characterize associated complications.
methodsAmong 198 patients initially treated with GKS for TN, 34 (17.2%) underwent a second procedure due to recurrent or persistent pain. After applying the eligibility criteria, 25 patients were analyzed. Factors associated with retreatment were assessed, and complications and pain relief outcomes following repeat GKS were evaluated.
resultsPrior microvascular decompression (MVD) and lower initial radiation dose were significantly associated with need for retreatment (p < 0.001 and p = 0.014, respectively). Neurovascular conflict and prior rhizotomy were not statistically significant predictors. Facial hypoesthesia was the most common complication after repeat GKS (64%). Repeat treatment yielded moderate pain relief in most patients, but durable long-term benefit was limited, consistent with literature reporting 40-60% efficacy.
conclusionsRepeat GKS is a valuable option for recurrent TN but presents a risk of sensory complications. Prior MVD and lower initial dose are important predictors of retreatment necessity, guiding individualized patient counseling and treatment planning.
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Registered trials
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