Evidence map›Paper›PMID 40771992›Full record

ReviewNpj biological timing and sleep2025

Revisiting brain gene expression changes and protein modifications tracking homeostatic sleep pressure.

Valérie Mongrain, Marcos G Frank, Tanya Leduc

Abstract readReview
In one paragraph

Review in Npj biological timing and sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Valérie MongrainDepartment of Neuroscience, Université de Montréal, Montréal, QC Canada.
Marcos G FrankDepartment of Translational Medicine and Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA USA.
Tanya LeducDepartment of Neuroscience, Université de Montréal, Montréal, QC Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review describes how transcriptomic/proteomic studies have contributed identifying molecular markers of sleep homeostasis and offers a perspective on the need to interrogate more comprehensively different dynamics, brain regions, and cell types. Modifications in molecular dynamics with development/aging are also emphasized. We suggest the concept of sleep homeostasis to be regarded as a variety of homeostats (not a single one) serving different functions for the brain across the lifespan.

Indexed as

BiochemistryBiological techniquesDevelopmental biologyNeuroscience

Identifiers

PMID40771992
PMCPMC12321568

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.