SynthesisFrontiers in neurology2025
Global collaboration and innovation in malignant cerebral edema research: a bibliometric perspective.
Synthesis in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Severe trauma care: advances and future directions in diagnostic and therapeutic techniques and information technology support.Medical review (2021) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: Malignant cerebral edema (MCE) is a life-threatening complication of acute brain injuries, with mortality rates exceeding 80% in the absence of treatment. Despite advancements in osmotic therapies and decompressive craniectomy (DC), MCE continues to pose substantial clinical challenges. This study systematically maps the evolution of MCE research (2005-2024) to identify key trends, research gaps, and future priorities. Methods: A bibliometric analysis of 1,460 peer-reviewed articles from the Web of Science Core Collection was conducted using CiteSpace, VOSviewer, and Bibliometrix. Key metrics included publication trends, geographic and institutional contributions, keyword co-occurrence, citation networks, and co-authorship patterns. Results: Annual publications increased from 55 in 2005 to 128 in 2024, progressing through three distinct phases: Foundational growth (2005-2009), consolidation (2010-2014), and rapid expansion (2015-2024). The United States (28.9%) and China (18.7%) dominated research output, with Harvard University and the University of California System leading institutional collaboration clusters. High-impact journals highlighted clinical advancements, including Stroke (h-index = 27). Keyword analysis demonstrated a thematic progression from blood-brain barrier pathophysiology to clinical innovations, including DC and emerging predictive modeling techniques incorporating machine learning. Landmark trials, including DECIMAL and HAMLET, validated early surgical intervention, while emerging trends have emphasized precision medicine and artificial intelligence (AI)-driven risk stratification. Conclusion: The MCE research has transitioned from foundational pathophysiology to interdisciplinary clinical practice and data integration. However, critical gaps remain, including underrepresentation in pediatric research, disparities in global neurocritical care, and challenges in translational application. Future priorities should focus on biomarker discovery, equitable global collaborations, and AI-enhanced frameworks to transform survival into functional recovery worldwide.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.