ArticleGenes & cancer2025
Epstein-Barr virus nuclear antigen 1 upregulates
Article in Genes & cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundEpstein-Barr Virus (EBV), a potent viral carcinogen, plays a crucial role in the development of various malignancies. Among its proteins, EBV nuclear antigen-1 (EBNA1) stands out for its ability to modulate gene expression. In this study, we explored the impact of EBNA1 on the expression patterns of four cellular genes-Derlin1, ZEB1, CNN3, and PSMD10-in HeLa cells. MATERIALS AND
methodsThree distinct categories of HeLa cells were established: EBNA1-Transfected Cells: These cells were transfected with the EBNA1 gene.Control Plasmid-Transfected Cells: These cells received transfection with a control plasmid.Non-Transfected Cells (Control Group): These cells were not subjected to any transfection. After RNA extraction, we employed real-time PCR to evaluate the transcriptional levels of four specific genes-Derlin 1, ZEB1, CNN3, and PSMD10-in each of the three cell groups. The Mann-Whitney
resultsThe results demonstrated that HeLa cells transfected with the EBNA1 plasmid exhibited significantly increased expression levels of Derlin1 (
conclusionsOur findings suggest that increase expression levels of Derlin1 and PSMD10 genes in HeLa cells by the EBV-EBNA1 might induce cancer cell survival and accelerates the development of cervical cancer (CC). However, to establish a conclusive link between EBV-EBNA1 and CC progression, further investigations are warranted.
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