ReviewJournal of analytical methods in chemistry2025
Analytical Techniques for the Determination of Paracetamol and Ibuprofen Combination.
Review in Journal of analytical methods in chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fixed-dose combination (FDC) of ibuprofen (IBU) and paracetamol (PAR) has emerged as a preferred option in pain management, owing to its distinct practical advantages. Both drugs have well-documented efficacy and safety profiles, providing synergistic pain relief through complementary mechanisms of action. IBU not only offers central analgesic effects but also inhibits cyclooxygenase (COX) enzymes, particularly COX-1 and COX-2, thereby reducing prostaglandin synthesis at the site of pain to deliver both analgesic and anti-inflammatory benefits. Despite the growing use of this combination, a comprehensive review focusing on the analytical methods for its determination has not yet been published. This review aims to bridge that gap by presenting an extensive compilation of documented analytical methods for the quantification of IBU and PAR in both bulk and pharmaceutical formulations. It serves as a valuable resource for researchers and professionals seeking detailed insights into the diverse techniques employed for accurate and precise analysis of these FDCs. Through a systematic search of major scientific databases, including Science Direct, Springer Link, PubMed, Scopus, and Google Scholar, the review identifies the most commonly utilized methods, such as high-performance liquid chromatography (HPLC), gas chromatography (GC), high-performance thin-layer chromatography (HPTLC), ultraviolet (UV)/Visible spectrophotometry, Fourier-transform infrared spectroscopy (FTIR), and micellar electrokinetic chromatography (MEKC). Notably, HPLC and UV/Visible spectrophotometry were the most frequently reported, each accounting for 37.9% of studies. By consolidating these analytical approaches, this review highlights the state-of-the-art methodologies available for the determination of IBU/PAR FDCs and underscores its novel contribution as a definitive reference for future research and development in this field.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.