Evidence map›Paper›PMID 40771766›Full record

ArticleFrontiers in cardiovascular medicine2025

First-phase ejection fraction is associated with myocardial fibrosis in the pressure overloaded heart.

Shukun He, Jingrong Jiang, Yanting Zhang, Tianshu Liu, Wenhui Deng, Yuji Xie, Wenqu Li, Yuting Tan, Lingyun Fang, Jing Zhang and 8 more

Abstract read
PubMed Full text at PMC Publisher
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Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

18 authors.

Shukun He *Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jingrong Jiang *Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yanting Zhang *Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Tianshu LiuDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wenhui DengDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yuji XieDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wenqu LiDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yuting TanDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lingyun FangDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jing ZhangDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lin HeDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Qiaofeng JinDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yuman LiDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Li ZhangDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Phil ChowienczykClinical Pharmacology, St Thomas' Hospital, King's College London, London, United Kingdom.
Mingxing XieDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Haotian GuClinical Pharmacology, St Thomas' Hospital, King's College London, London, United Kingdom.
Jing WangDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: First-phase ejection fraction (EF1) has been recently demonstrated to sensitively detect early cardiac systolic dysfunction. However, the value of EF1 in predicting myocardial fibrosis (MF) has not been investigated. This study aimed to explore the relationship between EF1 and MF in the pressure overloaded heart. Methods: The pressure overloaded heart was induced by minimally invasive transverse aortic constriction (MTAC) in rats. Rats in the sham and MTAC groups were equally divided into different time points for examination, respectively. Echocardiography was conducted to validate the success of MTAC model and measure cardiac systolic function parameters. Subsequently, rat hearts underwent Masson's staining to measure the degree of MF. Results: Compared with sham group rats, MTAC group rats exhibited a significantly progressive impairment in EF1 starting from the 2nd week over observational period ( Conclusions: EF1 represents a highly sensitive and non-invasive marker for the early detection of cardiac systolic dysfunction and emerges as a promising indicator for the identification of MF in the early stage of pressure overloaded heart.

Indexed as

ejection fractionfirst-phase ejection fractionmyocardial fibrosismyocardial strainpressure overload

Identifiers

PMID40771766
PMCPMC12325372

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