ArticleWorld journal of clinical cases2025
Mediastinal lymphadenopathy: Causes, symptoms and factors predicting good yield of endoscopic ultrasound-guided biopsy.
Article in World journal of clinical cases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Hilar and Mediastinal Lymphadenopathy as a Potential Manifestation of Azathioprine-Associated Hypersensitivity Syndrome.Pharmaceuticals (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMediastinal lymph nodes (MLNs) can be enlarged due to various benign or malignant causes. Endoscopic ultrasound (EUS) is often employed for the acquisition of tissue specimens of the enlarged MLN (EMLN).
aimTo determine the causes, document the symptoms, and determine factors predicting good yield of EUS-guided EMLN biopsy.
methodsAll patients having EMLN (> 10 mm) on thoracic imaging and referred for EUS-guided biopsy were included in this retrospective observational study. Adequacy of the tissue specimen was assessed by the endoscopist with macroscopic on-site evaluation (MOSE) and then sent to a histopathologist for final diagnosis. Analysis for factors predicting good biopsy yield was then performed.
resultsOf the total 243 patients with EMLN, 131 (53.9%) were males. The mean age was 47.6 (± 14.7) and range 14-86 years. Commonest causes of EMLN were tuberculosis 82 (33.7%), anthracosis 53 (21.8%), neoplastic disease 43 (17.7%) and sarcoidosis 14 (5.8%). Among the 43 patients with neoplastic diseases: 40 had metastatic disease (breast 9, lung 7, pancreatobiliary 6, esophagus 5, kidney 5, hepatocellular 2, neuroendocrine 2, gastrointestinal stromal 1, undetermined 3) and 3 had primary malignancies (lymphoproliferative disorder 2, Kaposi sarcoma 1). Chest related clinical symptoms were absent in more than half the patients with tuberculosis 51/82 (62.2%), anthracosis 31/53 (58.5%) and neoplastic disease 28/43 (65.1%). Factors associated with good biopsy yield were: Subcarinal location of MLN (
conclusionTuberculosis, anthracosis and metastatic disease were the commonest causes of EMLN. More than half the cases with EMLN had no chest-related symptoms. Large MLN size and satisfactory MOSE observation predicted a good biopsy yield.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.