ArticleWorld journal of clinical cases2025
Anti-SSA/Ro antibody-positive autoimmune myocarditis combined with complete atrioventricular block requiring implantation with a permanent pacemaker: A case report.
Article in World journal of clinical cases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAutoimmune myocarditis (AM) associated with autoimmune diseases can cause complete atrioventricular block (CAVB), but the related autoantigens and the underlying mechanisms are unclear. Anti-SSA/Ro antibodies may play an important role in this process, but cases of AM with positive anti-SSA/Ro antibodies are rare. In addition, arrhythmias, such as atrioventricular block, are very common in patients with autoimmune diseases, but severe atrioventricular block requiring permanent pacemaker implantation is extremely rare. CASE SUMMARY: The patient in this case had AM with anti-SSA/Ro antibody positivity, which was associated with connective tissue disease, and the patient subsequently developed CAVB. After intensive immunosuppressive therapy, the antibody test results became negative, and pulmonary hypertension significantly improved. However, the outcome of permanent pacemaker implantation did not change.
conclusionIn clinical practice, the awareness of adult AM associated with autoimmune diseases combined with CAVB should be strengthened in clinicians, and anti-SSA/Ro antibodies may play a role in this process. Therefore, improving the detection of antibodies and early intervention, such as active immunosuppression therapy, may be very important for improving disease prognosis. For patients who do not respond to immunosuppressive therapy, implantation of a permanent pacemaker may become an essential treatment option.
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