ReviewFrontiers in bioengineering and biotechnology2025
Applications in osteochondral organoids for osteoarthritis research: from pathomimetic modeling to tissue engineering repair.
Review in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Multi‑omics approaches to decipher the molecular mechanisms of exercise‑mediated bone protection: From mechanistic insights to personalized exercise prescription (Review).Molecular medicine reports · 2026Review
- Vascularized bone organoids: current advances and a biomimetic platform for osteonecrosis of the femoral head.Bone research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis (OA) is a prevalent degenerative joint disorder characterized by complex tissue interactions, featuring cartilage degradation, synovitis, and aberrant subchondral bone remodeling. Current therapies often fail to halt disease progression and typically lack comprehensive strategies targeting OA pathogenesis. Osteochondral organoids have recently emerged as innovative 3D biological models for investigating OA mechanisms and developing personalized therapies. These models recapitulate dynamic cell-cell and cell-matrix interactions within the articular microenvironment. This review evaluates progress in applying osteochondral organoids to osteoarthritis, focusing on their fabrication strategies, applications, and key challenges. It emphasizes their role in osteoarthritis modeling, drug screening, and cartilage regeneration, while exploring future directions for their development. Despite these advances, clinical translation of osteochondral organoids faces significant challenges, including standardization, vascularization, and immunomodulation. Future integration with organ-on-chip platforms, multi-omics, and AI promises to create more precise OA research models. Such integration will bridge the gap between bench research and clinical practice.
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Registered trials
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