ArticleJGH open : an open access journal of gastroenterology and hepatology2025
Dose Performing Multiple Biopsy Strokes From the Same Site Improve Specimen Adequacy in Cholangioscopy-Guided Mapping Biopsy for Extrahepatic Cholangiocarcinoma?
Article in JGH open : an open access journal of gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Advances in Diagnosis and Treatment With Cholangiopancreatoscopy.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026Review
- Dose Performing Multiple Biopsy Strokes From the Same Site Improve Specimen Adequacy in Cholangioscopy-Guided Mapping Biopsy for Extrahepatic Cholangiocarcinoma?JGH open : an open access journal of gastroenterology and hepatology · 2025Article
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Authors and funding
13 authors.
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Abstract
Objectives: Cholangioscopy-guided mapping biopsy (CMB) is performed for preoperative evaluation of extrahepatic cholangiocarcinoma. The aim of this study was to evaluate the usefulness of CMB using a SpyBite Max and to determine the effectiveness of multiple biopsy strokes from the same site. Methods: Between August 2020 and October 2022, 21 patients with extrahepatic cholangiocarcinoma were enrolled in this prospective observational study. The primary outcome was the rate of site-based successful biopsies, which was defined as the acquisition of epithelium-containing material appropriate for diagnosing benignity/malignancy from each site. The cumulative success rate of obtaining appropriate materials increased by increasing biopsy strokes from 1 to 4. Results: The cholangioscope could be advanced to all 80 target sites. The overall adequate specimen rate was 67% (142/212). The overall rate of site-based successful biopsies was 83% (66/80). The cumulative success rate of obtaining appropriate materials did not significantly improve by increasing the number of biopsy strokes from 1 (81%) to 4 (86%). Conclusions: The biopsy material was obtained for 83% of the required sites. However, repetitive biopsy strokes for the same site did not improve the rate of site-based successful biopsy. This study was registered in UMIN (UMIN000041530).
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