Evidence map›Paper›PMID 40771632›Full record

ReviewTransactions of the American Clinical and Climatological Association2025

THERAPIES FOR NEONATAL DISEASES OF THE SURFACTANT SYSTEM.

Paul B McCray

Abstract readReview
In one paragraph

Review in Transactions of the American Clinical and Climatological Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Paul B McCrayIowa City, IA.

Funding

Impact of ATP-binding cassette A3 (ABCA3) mutations on alveolar type 2 cell function and genetic complementationR03TR004814 · NCATS · UNIVERSITY OF IOWA · PI MCCRAY, PAUL B · 2024 to 2024
$173k
NCATS NIH HHS R03 TR004814
6 · The paper itself

Abstract

A critical adaptation required for successful extrauterine life is the onset of respiration. The production of pulmonary surfactant by alveolar type II (AT2) cells is required for functional ventilation. Pulmonary surfactant is produced in lamellar bodies in AT2 cells. Key components of pulmonary surfactant include phospholipids and surfactant proteins B (SP-B) and C (SP-C). Phospholipids are transported into lamellar bodies by ATP-binding cassette subfamily A member 3 (ABCA3) where they combine with SP-B and -C to form surfactant that is secreted into alveoli. Recessive loss of function mutations in surfactant protein B (

Indexed as

Genetic TherapyLung Diseases, InterstitialPulmonary SurfactantsRespiratory Distress Syndrome, NewbornAnimalsATP-Binding Cassette TransportersGene EditingHumansInfant, NewbornMutationPulmonary Surfactant-Associated Protein BPulmonary Surfactant-Associated Protein CABCA3 protein, humanATP-Binding Cassette TransportersPulmonary Surfactant-Associated Protein BPulmonary Surfactant-Associated Protein CPulmonary SurfactantsSFTPC protein, human

Identifiers

PMID40771632
PMCPMC12323473

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.