Evidence map›Paper›PMID 40771625›Full record

ReviewTransactions of the American Clinical and Climatological Association2025

BREAST CANCER: STEPS AND STUMBLES ON THE WAY TO PRECISION MEDICINE.

Lisa A Carey

Abstract readReview
In one paragraph

Review in Transactions of the American Clinical and Climatological Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Lisa A CareyChapel Hill, NC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treating breast cancer is both a success story and a lesson in the challenges of tailoring treatment to need. Beginning in the 1980s, multiple initiatives minimized surgical intervention and toxicity, integrated radiation therapy, and began to incorporate increasingly targeted medical therapy. Because of advances in treatment and screening, the U.S. mortality from breast cancer has dropped over 40%. However, these advances have come at a financial, physical, and social cost. It costs nearly $30 billion per year in the United States to achieve these improved outcomes in treating breast cancer, and we know that we overtreat many patients. Moreover, racial disparities in outcome persist, and many patients cannot access modern treatments. Ensuring that we give the right treatment to the right patient, and that we omit therapy when it is safe to do so, will require new strategies.

Indexed as

Breast NeoplasmsPrecision MedicineBiomarkers, TumorFemaleHealthcare DisparitiesHumansUnited StatesBiomarkers, Tumor

Identifiers

PMID40771625
PMCPMC12323461

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.