Evidence map›Paper›PMID 40771583›Full record

ArticleTheranostics2025

The LRP4/YAP axis drives the radiation-tolerant persister (RTP) cell state in breast cancer.

Violaine Forissier, Julien Wicinski, Martin Castagné, Guillaume Pinna, Shuheng Lin, Anaïs Grandon, Caroline Bonnet, Manon Macario, Remy Castellano, Simon Valdenaire and 4 more

Abstract read
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Decoding the breast cancer microenvironment by spatial multi-omics: from architecture to clinical translation.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Violaine ForissierCRCM, Inserm, CNRS, Institut Paoli-Calmettes, Aix-Marseille Univ, Epithelial Stem Cells an Cancer Lab, Equipe labellisée LIGUE contre le cancer, Marseille, France.
Julien WicinskiCRCM, Inserm, CNRS, Institut Paoli-Calmettes, Aix-Marseille Univ, Epithelial Stem Cells an Cancer Lab, Equipe labellisée LIGUE contre le cancer, Marseille, France.
Martin CastagnéCRCM, Inserm, CNRS, Institut Paoli-Calmettes, Aix-Marseille Univ, Epithelial Stem Cells an Cancer Lab, Equipe labellisée LIGUE contre le cancer, Marseille, France.
Guillaume PinnaPlateforme ARN Interférence (PARI), Université Paris Cité, Inserm, CEA Stabilité Génétique Cellules Souches et Radiations, Fontenay-aux-Roses, France.
Shuheng LinCRCM, Inserm, CNRS, Institut Paoli-Calmettes, Aix-Marseille Univ, Epithelial Stem Cells an Cancer Lab, Equipe labellisée LIGUE contre le cancer, Marseille, France.
Anaïs GrandonCRCM, Inserm, CNRS, Institut Paoli-Calmettes, Aix-Marseille Univ, Epithelial Stem Cells an Cancer Lab, Equipe labellisée LIGUE contre le cancer, Marseille, France.
Caroline BonnetCRCM, Inserm, CNRS, Institut Paoli-Calmettes, Aix-Marseille Univ, Epithelial Stem Cells an Cancer Lab, Equipe labellisée LIGUE contre le cancer, Marseille, France.
Manon MacarioCRCM, Inserm, CNRS, Institut Paoli-Calmettes, Aix-Marseille Univ, Epithelial Stem Cells an Cancer Lab, Equipe labellisée LIGUE contre le cancer, Marseille, France.
Remy CastellanoAix-Marseille Univ, Inserm, CNRS, Institut Paoli-Calmettes, TrGET Plateform, Marseille, France.
Simon ValdenaireDepartment of Medical Physics, Institut Paoli-Calmettes, Marseille, France.
Julien DarréonDepartment of Medical Physics, Institut Paoli-Calmettes, Marseille, France.
Agnès TalletCRCM, Inserm, CNRS, Institut Paoli-Calmettes, Aix-Marseille Univ, Epithelial Stem Cells an Cancer Lab, Equipe labellisée LIGUE contre le cancer, Marseille, France.
Christophe GinestierCRCM, Inserm, CNRS, Institut Paoli-Calmettes, Aix-Marseille Univ, Epithelial Stem Cells an Cancer Lab, Equipe labellisée LIGUE contre le cancer, Marseille, France.
Emmanuelle Charafe-JauffretCRCM, Inserm, CNRS, Institut Paoli-Calmettes, Aix-Marseille Univ, Epithelial Stem Cells an Cancer Lab, Equipe labellisée LIGUE contre le cancer, Marseille, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adaptor Proteins, Signal TransducingBreast NeoplasmsNeoplastic Stem CellsRadiation ToleranceTranscription FactorsAnimalsCell Line, TumorCell PlasticityFemaleHumansMiceXenograft Model Antitumor AssaysYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingTranscription FactorsYAP1 protein, humanYAP-Signaling Proteinsbreast cancercancer stem cellcell plasticityLRP4radiation therapyYAP

Identifiers

PMID40771583
PMCPMC12325171

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.