ReviewFrontiers in cellular neuroscience2025
Proximity labeling uncovers the synaptic proteome under physiological and pathological conditions.
Review in Frontiers in cellular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Review
- Fluorescent Labeling Methods for Brain Structure Research.Molecules (Basel, Switzerland) · 2026Review
- Astrocyte-Mediated Plasticity: Multi-Scale Mechanisms Linking Synaptic Dynamics to Learning and Memory.Cells · 2025Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synapses are fundamental units of neurotransmission and play a central role in the formation and function of neural circuits. These dynamic structures exhibit morphological and functional plasticity in response to experience and activity, supporting higher brain functions such as learning, memory, and emotion. Their molecular composition includes diverse membrane-associated and cytoskeletal proteins that mediate intercellular signaling, regulate synaptic plasticity, and maintain structural stability. Disruptions in these protein networks, often referred to as synaptopathies, are closely linked to psychiatric and neurological disorders. Such disruptions commonly manifest as region-specific changes in synapse number, morphology, or signaling efficacy. Although a large number of synaptic proteins have been identified through conventional proteomic approaches, our understanding of synaptic specificity and plasticity remains limited. This is primarily due to insufficient spatial resolution, lack of cell-type specificity, and challenges in applying these methods to intact neural circuits
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.