ArticleFrontiers in medicine2025
High-flow nasal cannula oxygenation reduces desaturation during percutaneous radiofrequency ablation under moderate sedation.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05212064 (High-flow Nasal Cannula Oxygen Therapy and Hypoxia/Desaturation During Percutaneous Radiofrequency Ablation Under Moderate Sedation), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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High-flow Nasal Cannula Oxygen Therapy and Hypoxia/Desaturation During Percutaneous Radiofrequency Ablation Under Moderate Sedation: A Randomized Clinical Trial
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7 authors.
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Abstract
Background: The majority of percutaneous radiofrequency ablation (PRFA) procedures for liver cancer are performed under ultrasound guidance and with moderate sedation. Oxygen desaturation is one of the most common and concerning adverse events that can be challenging to prevent during this procedure. High-flow nasal cannula (HFNC) oxygen therapy is effective in delivering high oxygen flow rates. This study aimed to evaluate the safety of HFNC oxygen therapy in preventing oxygen desaturation in patients undergoing ultrasound-guided PRFA with moderate sedation. Methods: In this prospective, randomized controlled study, 100 patients who underwent ultrasound-guided PRFA with moderate sedation were randomly divided into two groups: a low-flow oxygen group (6 L/min via an HFNC) and a high-flow oxygen group (40 L/min via an HFNC). The primary outcome was oxygen desaturation. Other adverse events were also recorded. Results: Patients who received high-flow oxygen (40 L/min) had a lower incidence of mild desaturation (0% vs. 6%, Conclusion: In patients undergoing ultrasound-guided PRFA with moderate sedation, high-flow oxygen therapy at 40 L/min through HFNC therapy resulted in higher average oxygen saturation levels and a reduced incidence of oxygen desaturation-particularly moderate and severe desaturation-compared to low-flow oxygen therapy at 6 L/min. Clinical trial registration: Identifier NCT05212064.
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