ArticleChemical science2025
Photocatalytic regioselective four-component radical relay carbonylation for α-aminoketones synthesis.
Article in Chemical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Lewis acid/NHC dual catalysis for regioselective vicinal decarboxylative carbonylation-acylation of alkenes.Chemical science · 2026Article
- Zinc-Mediated Four-Component Carbonylation toward Direct Synthesis of α-Amino Ketones.Organic letters · 2026Article
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2 authors.
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Abstract
Regioselective transformation is among the long-standing challenges in organic synthesis, particularly involving gas trapping. We present here a novel photocatalytic strategy for the regioselective carbonylation reaction toward α-aminoketones. Experimental studies reveal that protonic acids dissociated from protonated amines facilitate the reactions of low-reactive aldehydes and enhance the electrophilicity of imines, thereby promoting the efficient coupling of less nucleophilic acyl radicals. This approach introduces a reliable framework for controlling regioselectivity in photocatalytic multi-radical-coupled CO trapping reactions, broadens the chemical space of α-aminoketones, and advances carbonylation reactions for sustainable development.
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