Evidence map›Paper›PMID 40771313›Full record

ArticleFrontiers in cellular and infection microbiology2025

Prevention of donation-related infections: investigating the use of antibiotics in the decontamination of preservation fluid for organ transplantation.

Yazhe Duan, Junhao Yu, Pei Zhang, Yuhong Li, Kewen Chen, Yanfeng Li, Yuxiang Wan, Kang Wu, Li Zeng, Yanhua Li and 1 more

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Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Yazhe DuanDepartment of Organ Transplantation, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
Junhao YuDepartment of Organ Transplantation, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
Pei ZhangDepartment of Organ Transplantation, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
Yuhong LiDepartment of Organ Transplantation, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
Kewen ChenDepartment of Organ Transplantation, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
Yanfeng LiDepartment of Organ Transplantation, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
Yuxiang WanDepartment of Laboratory Diagnostics, Shanghai Changhai Hospital, Shanghai, China.
Kang WuDepartment of Laboratory Diagnostics, Shanghai Changhai Hospital, Shanghai, China.
Li ZengDepartment of Organ Transplantation, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
Yanhua LiDepartment of Organ Transplantation, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
Mingxing SuiDepartment of Organ Transplantation, The First Affiliated Hospital of Naval Medical University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Donation-related infections (DRIs), particularly those caused by carbapenem-resistant gram-negative bacteria (CRGNB), can have disastrous consequences because of their extensive drug resistance. Contamination during graft acquisition and transport can lead to DRIs, and the use of antibiotics in preservation fluid (PF) before organ transplantation can reduce the incidence of DRIs. This study was to determine and compare the effectiveness of different PF decontamination regimens to prevent CRGNB related DRIs. Methods: Twelve CRGNB strains were chosen to be the targets of decontamination, and a drug concentration gradient was established for each test drug based on the previous clinical research. In addition the standard decontamination procedures were performed to evaluate the antimicrobial effectiveness of polymyxin B (PB), colistin sulfate (CS), colistimethate sodium (CMS) and amikacin (AK) in the 0~4°C PF, and to explore the antimicrobial effects of CMS after different preprocessing methods. Results: PB and CS exhibited significantly better antimicrobial effectiveness against CRGNB than AK and CMS in the 0~4°C PF, and the antimicrobial effects on CRGNB increased with the increasing concentration of drugs. Notably, CMS after pretreatment (CMS-AP), its antibacterial was significantly enhanced at 4°C. Conclusions: The PF decontamination is important in preventing the DRIs caused by CRGNB, and the decontamination regimens based on PB or CS were confirmed effective. Notably, CMS could even achieve a better decontamination effect than PB after a simple and fast pretreatment.

Indexed as

Anti-Bacterial AgentsDecontaminationOrgan PreservationOrgan Preservation SolutionsOrgan TransplantationAmikacinColistinGram-Negative BacteriaGram-Negative Bacterial InfectionsHumansMicrobial Sensitivity TestsPolymyxin BTissue DonorsAmikacinAnti-Bacterial AgentsColistincolistinmethanesulfonic acidOrgan Preservation SolutionsPolymyxin BCRGNBdecontaminationdonation-related infectionpolymyxintransplant

Identifiers

PMID40771313
PMCPMC12325265

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.