Evidence map›Paper›PMID 40771281›Full record

ArticleFrontiers in endocrinology2025

Case Report: Adrenocortical adenoma harboring atypical subclinical Cushing's syndrome with dehydroepiandrosterone sulfate transferase and cytochrome b5 expression in tumor cells.

Ichiro Abe, Yuto Yamazaki, Ayuko Higashi, Kentaro Ochi, Keita Kubo, Yuya Fujita, Kaori Takeshita, Toshiaki Wada, Ryo Mitsuoka, Yo Yamashita and 9 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Ichiro Abe *Department of Endocrinology and Diabetes Mellitus, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, Japan.
Yuto Yamazaki *Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Ayuko Higashi *Department of Endocrinology and Diabetes Mellitus, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, Japan.
Kentaro OchiDepartment of Endocrinology and Diabetes Mellitus, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, Japan.
Keita KuboDepartment of Endocrinology and Diabetes Mellitus, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, Japan.
Yuya FujitaDepartment of Endocrinology and Diabetes Mellitus, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, Japan.
Kaori TakeshitaDepartment of Endocrinology and Diabetes Mellitus, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, Japan.
Toshiaki WadaDepartment of Endocrinology and Diabetes Mellitus, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, Japan.
Ryo MitsuokaDepartment of Endocrinology and Diabetes Mellitus, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, Japan.
Yo YamashitaDepartment of Endocrinology and Diabetes Mellitus, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, Japan.
Ryoko YoshidaDepartment of Endocrinology and Diabetes Mellitus, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, Japan.
Tamotsu KatoDepartment of Endocrinology and Diabetes Mellitus, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, Japan.
Tadachika KudoDepartment of Endocrinology and Diabetes Mellitus, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, Japan.
Shigero MiyajimaDepartment of Urology, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, Japan.
Tatsu IshiiDepartment of Urology, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, Japan.
Satoshi NimuraDepartment of Pathology, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, Japan.
Takashi SuzukiDepartment of Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Hironobu SasanoDepartment of Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Kunihisa KobayashiDepartment of Endocrinology and Diabetes Mellitus, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subclinical Cushing's syndrome (SCS) is frequently encountered during the clinical evaluation of adrenal incidentalomas and is typically associated with reduced levels of serum dehydroepiandrosterone sulfate (DHEA-S). Cytochrome b5 is a component of the electron transfer system that enhances the activity of 17, 20-lyase relative to that of 17a-hydroxylase. Therefore, tumors harboring cytochrome b5 might be associated with dehydroepiandrosterone sulfotransferase (DHEA-ST) expression, resulting in unsuppressed serum DHEA-S levels. Here, we reported the first case of SCS with elevated serum DHEA-S levels in an incidentally detected adrenocortical adenoma showing immunohistochemical positivity for both cytochrome b5 and DHEA-ST.

Indexed as

Adrenal Cortex NeoplasmsAdrenocortical AdenomaCushing SyndromeCytochromes b5SulfotransferasesDehydroepiandrosterone SulfateFemaleHumansMiddle AgedCytochromes b5Dehydroepiandrosterone SulfateSulfotransferasescytochrome b5dehydroepiandrosteroneelectron transfer systemhypercortisonemiasubclinical Cushing’s syndrome

Identifiers

PMID40771281
PMCPMC12326150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.