SynthesisFrontiers in endocrinology2025
Obstetric and perinatal outcomes in pregnancies conceived with donor versus partner sperm: a systematic review and meta-analysis.
Synthesis in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Donor versus partner sperm in IVF/ICSI: risk of preeclampsia and obstetric outcomes in a prospective registry-linkage study.Journal of assisted reproduction and genetics · 2026Article
- Differences in Maternal and Neonatal Outcomes Between Pregnancies Following Intrauterine Insemination (IUI) and In Vitro Fertilization (IVF): A Review.Journal of clinical medicine · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Male-related factors contribute to 30-40% of infertility cases, with donor sperm serving as a critical solution for severe male infertility or paternally inherited genetic disorders. While cryopreservation ensures virological safety, concerns persist regarding sperm DNA damage, oxidative stress, and epigenetic impacts on embryogenesis. Previous studies have shown inconsistent evidence regarding obstetric and perinatal outcomes using donor versus partner sperm. This meta-analysis aimed to compare these outcomes to guide evidence-based clinical decisions. Methods: To identify studies published up to December 2024, we systematically search Embase, PubMed, Scopus, Wanfang, Web of Science, and China National Knowledge Infrastructure (CNKI). Studies investigating obstetric and perinatal outcomes using donor versus partner sperm were included regardless of the conception method. Adjusted estimates were prioritized, but crude estimates were utilized when necessary. Given the clinical and methodological heterogeneity, random-effects models were utilized to pool relative risks (RRs) and their 95% confidence intervals (CIs). Results: This analysis included 64 studies. Donor sperm was linked to better clinical pregnancy rates (RR 1.27, 95% CI 1.08-1.48) and decreased incidences of biochemical pregnancy (RR 0.85, 95% CI 0.81-0.88), miscarriage (RR 0.91, 95% CI 0.84-1.00), very preterm birth (RR 0.88, 95% CI 0.80-0.96), and very low birth weight (RR 0.89, 95% CI 0.81-0.98) compared with partner sperm. However, donor sperm conceptions exhibited increased risks of preeclampsia (RR 1.35, 95% CI 1.06-1.74) as well as pregnancy-induced hypertension (RR 1.19, 95% CI 1.05-1.36). For other outcomes, including gestational diabetes mellitus, ectopic pregnancy, placental abruption, placenta previa, large and small for gestational age, preterm birth, high and low birth weight, perinatal death, stillbirth, neonatal death, and congenital anomalies, no significant disparities were observed. Conclusions: Donor sperm offers improved pregnancy outcomes for severe male infertility or paternally inherited genetic disorders but is linked to elevated risks of preeclampsia and pregnancy-induced hypertension. Additional studies are required to explore potential mechanisms and design specific interventions.
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