ArticlePlastic and reconstructive surgery. Global open2025
Efficacy of Combined Use of PELNAC and Platelet-rich Plasma in Promoting Wound Healing.
Article in Plastic and reconstructive surgery. Global open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Background: Artificial dermis is useful for treating full-thickness skin defects but requires a long time to form dermis-like granulation tissue. This study investigated whether platelet-rich plasma (PRP) combined with PELNAC, a collagen-based artificial dermis, promotes wound healing and examined the underlying mechanism. Methods: Two 1-cm² full-thickness skin defects were created in 8-week-old male nude rats (n = 8). One defect received saline-impregnated PELNAC (control group); the other received PRP-impregnated PELNAC (combination group). Cytokine levels in PRP were measured. Wound area measurements and histological and immunohistochemical evaluations (transforming growth factor-β1 [TGF-β1], vascular endothelial growth factor [VEGF], α-smooth muscle actin, and von Willebrand factor) were performed on day 14. Results: Compared with the control group, the combination group showed a significantly reduced wound area (32.4 ± 14.89 versus 68.3 ± 14.9 mm², Conclusions: The combined use of PELNAC and PRP accelerated dermis-like granulation tissue formation through increased expression of VEGF and transforming growth factor-β1, significantly improving wound healing. This combination therapy could be easily applied in clinical practice and may contribute to shortening healing times for deep dermal defects.
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