Evidence map›Paper›PMID 40771211›Full record

ArticleFrontiers in nutrition2025

A mixed methods feasibility study of a ketogenic diet as treatment for Parkinson's disease.

Kate Worster, Dana Colgan, Alexandra Vita, Christine McClure, Lita Buttolph, Romilly Hodges, Angela Senders, Andy Erlandsen, Fawzy Elbarbry, Heather Zwickey

Abstract read
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Ketogenic diet and Parkinson's disease.Frontiers in molecular neuroscience · 2026
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kate WorsterHelfgott Research Institute, National University of Natural Medicine, Portland, OR, United States.
Dana ColganHelfgott Research Institute, National University of Natural Medicine, Portland, OR, United States.
Alexandra VitaHelfgott Research Institute, National University of Natural Medicine, Portland, OR, United States.
Christine McClureHelfgott Research Institute, National University of Natural Medicine, Portland, OR, United States.
Lita ButtolphHelfgott Research Institute, National University of Natural Medicine, Portland, OR, United States.
Romilly HodgesHelfgott Research Institute, National University of Natural Medicine, Portland, OR, United States.
Angela SendersHelfgott Research Institute, National University of Natural Medicine, Portland, OR, United States.
Andy ErlandsenHelfgott Research Institute, National University of Natural Medicine, Portland, OR, United States.
Fawzy ElbarbrySchool of Pharmacy, Pacific University, Hillsboro, OR, United States.
Heather ZwickeyHelfgott Research Institute, National University of Natural Medicine, Portland, OR, United States.

Funding

CAM Research Training in Neuroscience &StressT32AT002688 · NCCIH · OREGON HEALTH & SCIENCE UNIVERSITY · PI OKEN, BARRY S, SOUMYANATH, AMALA · 2005 to 2025
$7.2M
Building Research across Interdisciplinary Gaps (BRIDG) R90 Training Program - Administrative SupplementR90AT008924 · NCCIH · NATIONAL UNIVERSITY OF NATURAL MEDICINE · PI BRADLEY, RYAN D, ZWICKEY, HEATHER LEA · 2015 to 2025
$5.2M
NCCIH NIH HHS R90 AT008924NCCIH NIH HHS T32 AT002688
6 · The paper itself

Abstract

Objective: People with Parkinson's disease (PD) have been shown to benefit from a ketogenic diet (KD). However, evidence suggests the traditional KD's high dairy consumption may exacerbate PD symptoms. This patient-initiated study assessed the feasibility and acceptability of a novel ketogenic diet limiting dairy products in patients with PD. Quality of life and functional movements were also evaluated. Methods: Twelve people with PD followed a modified, low dairy KD for 12 weeks. We provided support and nutritional education to assist with adherence. Subjects recorded daily food diaries, from which total macronutrients were calculated. Every 4 weeks blood (complete blood count (CBC), lipid panel, vitamin D, beta-hydroxybutyrate, electrolytes), urinalysis (calcium, creatinine), vitals, height, weight, quality of life [Parkinson's Disease Questionnaire-39 (PDQ-39)] and functional movement assessments [Unified Parkinson's Disease Rating Scale (UPDRS), Freezing of Gait, mini-Balance Evaluation Systems Test (mini-BEST), 360° Turn] were collected. Results: All subjects completed the study and 75% recorded at least three-quarters of their daily food diary entries. Average macronutrient levels (70% fat, 18% protein, 5% net carbohydrate) and beta-hydroxybutyrate levels ( Conclusion: This exploratory study deemed the modified ketogenic diet feasible and acceptable. Findings suggest a low dairy KD may provide similar benefits to a traditional KD for those with PD, while reducing potential risks associated with consuming higher amounts of animal dairy products.

Indexed as

glucosegut microbiomeinflammationketogenic dietParkinson’s diseasepatient-initiated

Identifiers

PMID40771211
PMCPMC12325006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.