ArticleJournal of the International Society of Sports Nutrition2025
Elevated extracellular water to total body water ratio and low phase angle in relation to muscle function in middle-aged and older adults.
Article in Journal of the International Society of Sports Nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Article
- Article
- Beyond Fluid Distribution: Synergistic Bioelectrical Impedance Analysis Metrics for Refined Sarcopenia Screening.JMA journal · 2026Article
- Article
- Phase angle, extracellular to intracellular water ratio, and advanced glycation end products according to four sarcopenia categories and in relation to muscle strength/mass in elderly out-patients with diabetes.Diabetology international · 2026Article
- Water Distribution in the Body as a Source of Information on Markers of Skeletal Muscle Ageing.Nutrients · 2026Article
- Semaglutide Plus Low-Dose Metformin Combination Therapy for the Treatment of Obesity and Prediabetes in a Woman with Partial Deletion of the X Chromosome Long Arm.Reports (MDPI) · 2026Article
- Article
- Extracellular-to-total body water ratio is associated with comorbidity and cardiorespiratory fitness in older adults with post-COVID-19 syndrome.Frontiers in nutrition · 2026Article
- NRS2002-stratified body composition and laboratory characteristics in hospitalized cancer patients assessed by bioelectrical impedance analysis.Frontiers in nutrition · 2026Article
- Article
- Association between phase angle and ECW/TBW ratio with body composition in individuals with central obesity: a cross-sectional study.Frontiers in nutrition · 2025Article
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Authors and funding
12 authors.
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Abstract
backgroundDecline in muscle function is a major health concern in aging populations, increasing the risk for disability and frailty. Bioelectrical impedance analysis (BIA) offers a practical method to assess physiological status in community settings. BIA-derived parameters include the phase angle (PhA), an indicator of cellular health and integrity, and the extracellular water to total body water (ECW/TBW) ratio, which reflects fluid balance and systemic inflammation. Objective: While these markers have been independently linked to adverse health outcomes, their combined utility for stratifying the risk of functional decline remains underexplored. This study aimed to investigate the joint association of PhA and ECW/TBW status with poor muscle function in middle-aged and older adults.
methodsThis cross-sectional study included 695 community-dwelling adults aged ≥ 50 years (mean age 75.7 ± 8.9 years; 21.4% male; mean BMI 24.6 ± 3.6 kg/m
resultsAfter adjustment for demographic and clinical confounders, the Lower PhA/Elevated ECW/TBW group showed significant associations with both low physical function (OR = 3.07, 95% CI = 1.63-5.81) and low grip strength (OR = 2.41, 95% CI = 1.20-4.85), as well as their co-occurrence (OR = 3.10, 95% CI = 1.53-6.27). No significant associations were found for the Normal PhA/Elevated ECW/TBW group after adjustment.
conclusionThe combination of a lower PhA and an elevated ECW/TBW ratio is significantly associated with poor muscle function. This combined BIA profile may serve as a useful, noninvasive screening tool for identifying individuals at high risk of functional decline in community settings.
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