ArticleEuropean journal of haematology2025
Effectiveness of Octocog Alfa (BAY 81-8973) to Treat People With Haemophilia A Enrolled in the ATHNdataset, Including Under-Represented Subgroups.
Article in European journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Effectiveness of Octocog Alfa (BAY 81-8973) to Treat People With Haemophilia A Enrolled in the ATHNdataset, Including Under-Represented Subgroups.European journal of haematology · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
objectivesTo evaluate the real-world effectiveness of octocog alfa (BAY 81-8973; Kovaltry) in people with haemophilia A (PwHA), including under-represented subgroups.
methodsWe retrospectively analysed the American Thrombosis and Hemostasis Network (ATHN) dataset to identify the characteristics, treatment/clinical histories and annualised bleeding rates (ABRs) of PwHA receiving prophylactic or on-demand octocog alfa. Subgroup analyses included females and those switching to octocog alfa. Data are reported descriptively.
resultsAmong 270 PwHA treated with octocog alfa with available bleeding rate data between 1 January 2010 and 31 October 2020, mean (standard deviation) total ABRs were low (0.59 [2.22]) and > 70% of those treated for > 12 months had 0 bleeds. At the second data cutoff (30 April 2022; n = 354), subgroups who switched to octocog alfa from previous treatment had low mean total ABRs after switching, including adolescents (0.83; n = 22), and those previously receiving emicizumab (0.17; n = 17). In females, 10/11 reported 0 bleeds, and of those with joint range of motion data available (n = 5), 100% had values ≥ 10% below the normal range in ≥ 2 joints.
conclusionsPwHA treated with octocog alfa in the ATHNdataset, including important subgroups, reported a low number of bleeds; thus, octocog alfa offers an effective therapeutic option.
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