Evidence map›Paper›PMID 40770896›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Activation of a Secondary-Messenger Receptor via Allosteric Modulation of a Dynamic Conformational Ensemble.

Benedikt Söldner, Himanshu Singh, Elias Akoury, Gregor Witte, Rasmus Linser

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Benedikt Söldner *Department of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, Dortmund, 44227, Germany.ORCID 0000-0003-2738-8263
Himanshu Singh *Department of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, Dortmund, 44227, Germany.ORCID 0000-0002-2819-6282
Elias Akoury *Department of Chemistry and Pharmacy, Ludwig-Maximilians University, Butenandtstrasse 5-13, Munich, 81377, Germany.ORCID 0000-0001-5202-8935
Gregor WitteGene Center, Ludwig-Maximilians University, Feodor-Lynen Strasse 25, Munich, 81377, Germany.ORCID 0000-0003-0313-0962
Rasmus LinserDepartment of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, Dortmund, 44227, Germany.ORCID 0000-0001-8983-2935

Funding

Deutsche Forschungsgemeinschaft 325871075Deutsche  Forschungsgemeinschaft 24286268Deutsche  Forschungsgemeinschaft 27112786Deutsche  Forschungsgemeinschaft 325871075Deutsche  Forschungsgemeinschaft 390677874Deutsche  Forschungsgemeinschaft Emmy Noether programEuropean Union 101082494
6 · The paper itself

Abstract

Bacterial signaling cascades have recently become of great relevance in the context of bacterial antibiotics resistance. Cyclic diadenylate monophosphate (c-di-AMP) is a key bacterial secondary messenger involved in growth, biofilm formation, virulence gene expression and others. The activation mechanisms of c-di-AMP receptors like the trimeric P

Indexed as

Bacterial ProteinsAllosteric RegulationNuclear Magnetic Resonance, BiomolecularProtein ConformationBacterial ProteinsConformational exchangeCyclic‐di‐AMPNuclear magnetic resonance spectroscopyProtein dynamicsSecondary messengers

Identifiers

PMID40770896
PMCPMC12435418

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.